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CGP 55845 hydrochloride

Name: CGP 55845 hydrochloride
Brand: Hello Bio
SKU: HB0960
Price: 173 USD
Availability: InStock
Rating: 100 (8 reviews)

(HB0960)

Publications (21)

Technical documents: SDS CoA Datasheet

Product overview

Name

CGP 55845 hydrochloride

Alternative names

CGP 55845, CGP-55845, CGP55845,

Purity

>98%

Customer comments

Works great! Switching to Hello Bio CGP 55845 from another supplier has saved us literally hundreds of dollars in the last year without sacrificing any quality at all! Indistinguishable in all regards except price. We love it! Verified customer, University of Toronto

Description

Potent, selective GABA_B receptor antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (8) Publications (21) References (3) Frequently bought together

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Images

CGP 55845 hydrochloride product vial image | Hello Bio

Biological Data

Biological description

CGP55845 hydrochloride is a potent and selective GABA_B receptor antagonist (IC₅₀ = 5 nM). It inhibits [3H]CGP 27492 binding (pK_i = 8.35).

CGP55845 hydrochloride inhibits GABA and glutamate release and inhibits GABA_B receptor responses to baclofen (IC₅₀ = 130 nM in an isoproterenol assay).

It enhances responses to hypoglycaemia and shows convulsive actions at high doses.

Solubility & Handling

Storage instructions

Room temperature

Solubility overview

Soluble in DMSO (100mM, gentle warming)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride

Molecular Weight

438.71

Chemical structure

Molecular Formula

C₁₈H₂₂Cl₂NO₃P.HCl

CAS Number

149184-22-5

PubChem identifier

5311042

SMILES

C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O

Source

Synthetic

InChi

InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1

InChiKey

ZODSPDOOCZZEIM-BBRMVZONSA-N

Appearance

White solid

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for CGP 55845 hydrochloride

References are publications that support the biological activity of the product

Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.
Zhang M et al (2007) J Physiol 578(Pt 3) : 735-50.
Read more (PubMedID: 17124268)
Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.
de Groote C et al (1999) Neuropharmacology 38(11) : 1683-9.
Read more (PubMedID: 10587084)
GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.
Waldmeier PC et al (1994) Br J Pharmacol 113(4) : 1515-21.
Read more (PubMedID: 7889310)

Publications

Submit Yours Now

These publications cite the use of CGP 55845 hydrochloride purchased from Hello Bio:

The dopamine neuron synaptic map in the striatum.
Chuhma N et al (2023) Cell reports 42 : 112204
PubMedID: 36867530
A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
Matityahu L et al (2022) Elife 11
PubMedID: 35579422
Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington's Disease Mice
Callahan JW et al (2022) J Neurosci 42(10) : 2080-2102
PubMedID: 35058372
Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders
Leuffe et al (2021) Transl Psychiatry . : 11(1)
PubMedID: 34650032
Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
Goldberg et al (2021) bioRxiv https://doi.org/10.1101/2021.11.29.470423 : doi

Potent, selective GABA_B receptor antagonist

Order: HB0960
Pack	Price	Qty
10mg	$173
50mg	$718

CGP 55845 hydrochloride

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for CGP 55845 hydrochloride

Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

The dopamine neuron synaptic map in the striatum.

A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington's Disease Mice

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders

Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

About you

Tell us about your publication!

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CGP 55845 hydrochloride

Product overview

Images

CGP 55845 hydrochloride product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for CGP 55845 hydrochloride

Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

The dopamine neuron synaptic map in the striatum.

A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington's Disease Mice

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders

Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

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Tell us about your publication!

Captcha

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