CGP 55845 hydrochloride

Technical documents: SDS CoA Datasheet

Product overview

Description Potent, selective GABAB receptor antagonist
Alternative names CGP 55845, CGP-55845
Purity >98%
Customer comments

Works great! Switching to Hello Bio CGP 55845 from another supplier has saved us literally hundreds of dollars in the last year without sacrificing any quality at all! Indistinguishable in all regards except price. We love it! Verified customer, University of Toronto

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Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
Molecular Weight 438.71
Chemical structure Product image
Molecular Formula C18H22Cl2NO3P.HCl
CAS Number 149184-22-5
PubChem identifier 5311042
SMILES C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O
Source Synthetic
InChi InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
Appearance White solid

References for CGP 55845 hydrochloride

References are publications that support the biological of the product
  • GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

    Waldmeier PC et al (1994) Br J Pharmacol 113(4) : 1515-21.
  • Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

    de Groote C et al (1999) Neuropharmacology 38(11) : 1683-9.
  • Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

    Zhang M et al (2007) J Physiol 578(Pt 3) : 735-50.
Publications are journal papers that use Hello Bio products. Selected Publications for CGP 55845 hydrochloride include:
  • Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2

    Nasrallah et al (2019) Cell Rep. 27(1) : 86-98
  • Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions

    Gonatopoulos-Pournatzis T et al (2020) Mol Cell 77(6) : 1176-1192
    PubMedID: 31999954
  • Structures of metabotropic GABAB receptor

    Papasergi-Scott et al. (2020) bioRxiv preprint : 1-37
  • Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.

    Gonatopoulos-Pournatzis et al. (2020) Mol Cell 77(6) : 1176-1192
    PubMedID: 31999954

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