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CGP 55845 hydrochloride

(HB0960)
Publications (21)
Technical documents: SDS CoA Datasheet
10  Reviews
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Product overview

Name CGP 55845 hydrochloride
Alternative names CGP 55845, CGP-55845, CGP55845,
Purity >98%
Customer comments

Works great! Switching to Hello Bio CGP 55845 from another supplier has saved us literally hundreds of dollars in the last year without sacrificing any quality at all! Indistinguishable in all regards except price. We love it! Verified customer, University of Toronto

Description Potent, selective GABAB receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (10) Publications (21) References (3) Frequently bought together
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Images

CGP 55845 hydrochloride product vial image | Hello Bio
CGP 55845 hydrochloride product vial image | Hello Bio

CGP 55845 hydrochloride product vial image | Hello Bio

CGP 55845 hydrochloride product vial image | Hello Bio

Biological Data

Biological description

CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist (IC50 = 5 nM). It inhibits [3H]CGP 27492 binding (pKi = 8.35).


CGP55845 hydrochloride inhibits GABA and glutamate release and inhibits GABAB receptor responses to baclofen (IC50 = 130 nM in an isoproterenol assay).


It enhances responses to hypoglycaemia and shows convulsive actions at high doses.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
Molecular Weight 438.71
Chemical structure CGP 55845 hydrochloride [149184-22-5] Chemical Structure
Molecular Formula C18H22Cl2NO3P.HCl
CAS Number 149184-22-5
PubChem identifier 5311042
SMILES C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O
Source Synthetic
InChi InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
InChiKey ZODSPDOOCZZEIM-BBRMVZONSA-N
Appearance White solid

References for CGP 55845 hydrochloride

References are publications that support the biological activity of the product

  • Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

    Zhang M et al (2007) J Physiol 578(Pt 3) : 735-50.
    Read more (PubMedID: 17124268)

  • Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

    de Groote C et al (1999) Neuropharmacology 38(11) : 1683-9.
    Read more (PubMedID: 10587084)

  • GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

    Waldmeier PC et al (1994) Br J Pharmacol 113(4) : 1515-21.
    Read more (PubMedID: 7889310)

3 Item(s)

Publications
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These publications cite the use of CGP 55845 hydrochloride purchased from Hello Bio:

  • Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion

    Robert BJA et al (2020) Cell Rep 31(10) : 107743
    PubMedID: 32521268

  • Structures of metabotropic GABAB receptor

    Papasergi-Scott et al. (2020) Nature. 7820 : 310-314
    PubMedID: 32580208

  • An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABAB/GIRK Signaling

    Druart M et al (2020) J Neurosci 40(44) : 8543-8555
    PubMedID: 33020214

  • Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors

    Bacon et al (2020) Cereb Cortex. 6135-6151 : 30(12)
    PubMedID: 32607551

  • Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.

    Gonatopoulos-Pournatzis et al. (2020) Mol Cell 77(6) : 1176-1192
    PubMedID: 31999954

Items 11 to 15 of 21 total

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10mg
$190
50mg
$790
Potent, selective GABAB receptor antagonist
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