CGP 52432

(HB0958)
Technical documents: CoA Datasheet
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Product overview

Name CGP 52432
Purity >99%
Description

Potent, selective GABAB receptor antagonist

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CGP 52432 product vial image | Hello Bio

Biological Data

Biological description

Potent and selective GABAB receptor antagonist (IC50 = 85 nM).

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl]diethoxymethyl)phosphinic acid
Molecular Weight 384.24
Chemical structure CGP 52432  [139667-74-6] Chemical Structure
Molecular Formula C15H24Cl2NO4P
CAS Number 139667-74-6
PubChem identifier 132252
SMILES ClC1=CC=C(CNCCCP(C(OCC)OCC)(O)=O)C=C1Cl
Source Synthetic
InChiKey GJZVQXWEIYRHBE-UHFFFAOYSA-N
MDL number MFCD09878290
Appearance White solid

References for CGP 52432

References are publications that support the biological activity of the product
  • Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action.

    Felice D et al (2012) Neuropharmacology 63(8) : 1380-8.
  • GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.

    Bonanno G et al (1998) Eur J Pharmacol 362(2-3) : 143-8.
  • CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex.

    Lanza M et al (1993) Eur J Pharmacol 237(2-3) : 191-5.

3 Item(s)

Publications
These publications cite the use of CGP 52432 purchased from Hello Bio:
  • Cholinergic activation of corticofugal circuits in the adult mouse prefrontal cortex.

    Gulledge AT (2023) bioRxiv : the preprint server for biology
    PubMedID: 37163128

1 Item