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Images
CGP 52432 product vial image | Hello Bio
CGP 52432 product vial image | Hello Bio
Biological Data
| Biological description | Potent and selective GABAB receptor antagonist (IC50 = 85 nM). |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in water (10mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl]diethoxymethyl)phosphinic acid |
| Chemical structure | ![CGP 52432 [139667-74-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "CGP 52432 [139667-74-6]") |
| Molecular Formula | C15H24Cl2NO4P |
| PubChem identifier | 132252 |
| SMILES | ClC1=CC=C(CNCCCP(C(OCC)OCC)(O)=O)C=C1Cl |
| InChiKey | GJZVQXWEIYRHBE-UHFFFAOYSA-N |
References for CGP 52432
References are publications that support the biological activity of the product
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Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action.
Felice D et al (2012) Neuropharmacology 63(8) : 1380-8. -
GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.
Bonanno G et al (1998) Eur J Pharmacol 362(2-3) : 143-8. -
CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex.
Lanza M et al (1993) Eur J Pharmacol 237(2-3) : 191-5.
Publications
These publications cite the use of CGP 52432 purchased from Hello Bio:
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Cholinergic activation of corticofugal circuits in the adult mouse prefrontal cortex.
Gulledge AT (2023) bioRxiv : the preprint server for biology
Potent, selective GABAB receptor antagonist
![CGP 52432 [139667-74-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0958.png "CGP 52432 [139667-74-6]")
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