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Images BINA product vial image | Hello Bio
BINA product vial image | Hello Bio Biological Data Biological description Potent and selective mGlu2 receptor positive allosteric modulator (EC50 = 33.2 nM). Shows anxiolytic, antipsychotic effects and decreases drug addiction behaviors in rats.
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7- dimethyl-1-oxo-1H -inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid
Chemical structure
Molecular Formula C30 H30 O4
PubChem identifier 9868580
SMILES CC1=C(C=C2CC(C(=O)C2=C1C)C3CCCC3)OCC4=CC=CC(=C4)C5=CC=C(C=C5)C(=O)O
InChi InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
InChiKey KMKBEESNZAPKMP-UHFFFAOYSA-N
References for BINA References are publications that support the biological activity of the product
The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. Jin X et al (2010) Neuropsychopharmacology 35(10) : 2021-36. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Benneyworth MA et al (2007) Mol Pharmacol 72(2) : 477-84. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. Galici R et al (2006) J Pharmacol Exp Ther 318(1) : 173-85.
Publications
These publications cite the use of BINA purchased from Hello Bio:
"Selective" Class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands Hellyer et al (2018) Molecular Pharmacology DOI: https://doi.org/10.1124/ : mol.117.111518
Potent, selective mGlu2 positive allosteric modulator
![BINA [866823-73-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0133.png "BINA [866823-73-6]")
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