Potent and selective mGlu2 receptor positive allosteric modulator (EC50 = 33.2 nM). Shows anxiolytic, antipsychotic effects and decreases drug addiction behaviors in rats.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
Room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.
Jin X et al (2010) Neuropsychopharmacology 35(10) : 2021-36.
Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
Galici R et al (2006) J Pharmacol Exp Ther 318(1) : 173-85.
![BINA [866823-73-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0133.png "BINA [866823-73-6]")
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