BINA

(HB0133)
Technical documents: SDS Datasheet

Product overview

Name BINA
Description Potent, selective mGlu2 positive allosteric modulator
Alternative names Biphenyl-indanone A; LS-193,571
Purity >98%
Customer comments

Your BINA behaved as expected. Verified customer, Monash University

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BINA: Scientist Approved

Biological Data

Biological description Potent and selective mGlu2 receptor positive allosteric modulator (EC50 = 33.2 nM). Shows anxiolytic, antipsychotic effects and decreases drug addiction behaviors in rats.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7- dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid
Molecular Weight 454.56
Chemical structure BINA  [866823-73-6] Chemical Structure
Molecular Formula C30H30O4
CAS Number 866823-73-6
PubChem identifier 9868580
SMILES CC1=C(C=C2CC(C(=O)C2=C1C)C3CCCC3)OCC4=CC=CC(=C4)C5=CC=C(C=C5)C(=O)O
InChi InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
InChiKey KMKBEESNZAPKMP-UHFFFAOYSA-N
MDL number MFCD19440914

References for BINA

References are publications that support the biological activity of the product
  • The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

    Jin X et al (2010) Neuropsychopharmacology 35(10) : 2021-36.
  • A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.

    Benneyworth MA et al (2007) Mol Pharmacol 72(2) : 477-84.
  • Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

    Galici R et al (2006) J Pharmacol Exp Ther 318(1) : 173-85.
Publications
These publications cite the use of BINA purchased from Hello Bio:
  • "Selective" Class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

    Hellyer et al (2018) Molecular Pharmacology DOI: https://doi.org/10.1124/ : mol.117.111518

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