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Charybdotoxin

(HB1052)
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Product overview

Name Charybdotoxin
Alternative names ChTx
Description Potent, selective KCa channel inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Images

Charybdotoxin product vial image | Hello Bio
Charybdotoxin product vial image | Hello Bio

Charybdotoxin product vial image | Hello Bio

Charybdotoxin product vial image | Hello Bio

Biological Data

Biological description Potent and selective KCa channel inhibitor (Kd = 3.5 nM). Displays high affinity for Kv1.3. Also a homotetrameric F425H channel blocker (Kd = 48 nM). Found in venom of the Leiurus quinquestriatus hebraeus scorpion.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Molecular Weight 4295.95
Molecular Formula C176H277N57O55S7
CAS Number 95751-30-7
PubChem identifier 102594130
SMILES [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)O
InChiKey CNVQLPPZGABUCM-UHFFFAOYSA-N

References for Charybdotoxin

References are publications that support the biological activity of the product

  • Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.

    Nikouee A et al (2012) J Phys Chem B 116(17) : 5132-40.
    Read more (PubMedID: 22490327)

  • Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels.

    Gao YD et al (2003) Proteins 52(2) : 146-54.
    Read more (PubMedID: 12833539)

  • Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.

    Thompson J et al (2000) Biophys J 78(5) : 2382-91.
    Read more (PubMedID: 10777734)

  • Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.

    Gimenez-Gallego G et al (1988) Proc Natl Acad Sci U S A 85(10) : 3329-33.
    Read more (PubMedID: 2453055)

4 Item(s)

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Order: HB1052
Pack PriceQty
100μg
$424
Potent, selective KCa channel inhibitor
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