Potent and selective KCa channel inhibitor (Kd = 3.5 nM). Displays high affinity for Kv1.3. Also a homotetrameric F425H channel blocker (Kd = 48 nM). Found in venom of the Leiurus quinquestriatus hebraeus scorpion.
Solubility & Handling
Solubility overview
Soluble in water (1mg/ml)
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.
Nikouee A et al (2012) J Phys Chem B 116(17) : 5132-40.