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Charybdotoxin

(HB1052)
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Product overview

Name Charybdotoxin
Alternative names ChTx
Description Potent, selective KCa channel inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Images

Charybdotoxin product vial image | Hello Bio
Charybdotoxin product vial image | Hello Bio

Charybdotoxin product vial image | Hello Bio

Charybdotoxin product vial image | Hello Bio

Biological Data

Biological description Potent and selective KCa channel inhibitor (Kd = 3.5 nM). Displays high affinity for Kv1.3. Also a homotetrameric F425H channel blocker (Kd = 48 nM). Found in venom of the Leiurus quinquestriatus hebraeus scorpion.

Solubility & Handling

Solubility overview Soluble in water (1mg/ml)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Molecular Weight 4295.95
Molecular Formula C176H277N57O55S7
CAS Number 95751-30-7
PubChem identifier 102594130
SMILES [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)O
InChiKey CNVQLPPZGABUCM-UHFFFAOYSA-N

References for Charybdotoxin

References are publications that support the biological activity of the product

  • Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.

    Nikouee A et al (2012) J Phys Chem B 116(17) : 5132-40.
    Read more (PubMedID: 22490327)

  • Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels.

    Gao YD et al (2003) Proteins 52(2) : 146-54.
    Read more (PubMedID: 12833539)

  • Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.

    Thompson J et al (2000) Biophys J 78(5) : 2382-91.
    Read more (PubMedID: 10777734)

  • Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.

    Gimenez-Gallego G et al (1988) Proc Natl Acad Sci U S A 85(10) : 3329-33.
    Read more (PubMedID: 2453055)

4 Item(s)

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Order: HB1052
Pack PriceQty
100μg
$437
Potent, selective KCa channel inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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