Product overview

Name Charybdotoxin
Alternative names ChTx
Description Potent, selective KCa channel inhibitor
Write Your Own Review
You're reviewing:Charybdotoxin
Rate this item:


Charybdotoxin product vial image | Hello Bio

Biological Data

Biological description Potent and selective KCa channel inhibitor (Kd = 3.5 nM). Displays high affinity for Kv1.3. Also a homotetrameric F425H channel blocker (Kd = 48 nM). Found in venom of the Leiurus quinquestriatus hebraeus scorpion.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Molecular Weight 4295.95
Molecular Formula C176H277N57O55S7
CAS Number 95751-30-7
PubChem identifier 102594130
SMILES [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)O

References for Charybdotoxin

References are publications that support the biological activity of the product
  • Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.

    Nikouee A et al (2012) J Phys Chem B 116(17) : 5132-40.
  • Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels.

    Gao YD et al (2003) Proteins 52(2) : 146-54.
  • Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.

    Thompson J et al (2000) Biophys J 78(5) : 2382-91.
  • Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.

    Gimenez-Gallego G et al (1988) Proc Natl Acad Sci U S A 85(10) : 3329-33.

4 Item(s)