Non-selective voltage-dependent Na+ and T-type Ca2+ channel blocker. Enhances BK(Ca) channels by increasing the time they are open. Scavenges free radicals and influences monoamine, glutamate and GABA neurotransmission. Acts as an anti-epileptic and shows neuroprotective and some anti-Parkinsonian actions.
Solubility & Handling
Solubility overview
Soluble in water (10mM) or DMSO (100mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Huang CW et al (2007) J Pharmacol Exp Ther 321(1) : 98-106.
![Zonisamide [68291-97-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0675.png "Zonisamide [68291-97-4]")
Understanding purity and quality - a guide for life scientists
