Product overview

Name Zonisamide
Description Non-selective Na+ / Ca2+ channel blocker
Alternative names AD 810, CI 912
Purity >99%
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Biological Data

Biological description Non-selective voltage-dependent Na+ and T-type Ca2+ channel blocker. Enhances BK(Ca) channels by increasing the time they are open. Scavenges free radicals and influences monoamine, glutamate and GABA neurotransmission. Acts as an anti-epileptic and shows neuroprotective and some anti-Parkinsonian actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (10mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1,2-Benzisoxazole-3-methanesulfonamide
Molecular Weight 212.22
Chemical structure Zonisamide  [68291-97-4] Chemical Structure
Molecular Formula C8H8N2O3S
CAS Number 68291-97-4
PubChem identifier 5734
SMILES NS(=O)(=O)CC1=NOC2=CC=CC=C12
InChiKey UBQNRHZMVUUOMG-UHFFFAOYSA-N

References for Zonisamide

References are publications that support the biological activity of the product
  • Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.

    Arawaka S et al (2014) PLoS One 9(2) : e89076.
  • Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.

    Huang CW et al (2007) J Pharmacol Exp Ther 321(1) : 98-106.
  • Zonisamide: a new antiepileptic drug.

    Sobieszek G et al (2003) Pol J Pharmacol 55(5) : 683-9.

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