Competitive antagonist of the widely used PIEZO1 channel activator Yoda1. Does not affect constitutive Piezo1 channel activity. Dooku1 is commonly used as an antagonist of Yoda1-induced effects. Shown to antagonize Yoda1-induced Piezo1 channel activation in endothelial cells, Yoda1-induced relaxxation of aorta ex vivo and also inhibits Yoda-1-induced Ca2+ entry in vitro.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
