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Dooku 1

(HB8740)
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Product overview

Name Dooku 1
Purity >98%
Description

Competitive antagonist of the widely used PIEZO1 channel activator Yoda1

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Reviews References (3)
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Biological Data

Biological description

Competitive antagonist of the widely used PIEZO1 channel activator Yoda1. Does not affect constitutive Piezo1 channel activity. Dooku1 is commonly used as an antagonist of Yoda1-induced effects. Shown to antagonize Yoda1-induced Piezo1 channel activation in endothelial cells, Yoda1-induced relaxation of aorta ex vivo and also inhibits Yoda1-induced Ca2+ entry in vitro.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Molecular Weight 326.2
Chemical structure Dooku [2253744-54-4] Chemical Structure
Molecular Formula C13H9Cl2N3OS
CAS Number 2253744-54-4
PubChem identifier 137321150
SMILES C1=CC(=C(C(=C1)Cl)CSC2=NN=C(O2)C3=CC=CN3)Cl
InChi InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2
InChiKey MNPOBXLPCWFONX-UHFFFAOYSA-N

References for Dooku 1

References are publications that support the biological activity of the product

  • Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.

    Jiang M et al (2023) British journal of pharmacology 180 : 1862-1877
    Read more (PubMedID: 36740831)

  • Dual action of Dooku1 on PIEZO1 channel in human red blood cells.

    Hatem A et al (2023) Frontiers in physiology 14 : 1222983
    Read more (PubMedID: 37492641)

  • Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.

    Evans EL et al (2018) British journal of pharmacology 175 : 1744-1759
    Read more (PubMedID: 29498036)

3 Item(s)

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Order: HB8740
Pack PriceQty
10mg
$117
50mg
$482

Competitive antagonist of the widely used PIEZO1 channel activator Yoda1

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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