Novel, Piezo1 channel agonist (MEC50 = 0.4µM). Modulates Piezo channels at concentrations ranging 0.4 to 1.8µM and is thought to stabilize the Piezo1 channel in its open confirmation. Induces Ca2+ influx in hCD4+ T-cells and may show potential vaccine adjuvant research usage. Show 10-fold improved kinetic solubility compared to Yoda1.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References are publications that support the biological activity of the product
Exploring the Structural Attributes of Yoda1 for the Development of New-Generation Piezo1 Agonist Yaddle1 as a Vaccine Adjuvant Targeting Optimal T Cell Activation.
Goon S et al (2024) Journal of medicinal chemistry 67 : 8225-8246
Understanding purity and quality - a guide for life scientists
