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UCPH 101

(HB0630)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name UCPH 101
Purity >98%
Description UCPH-101 is a potent, selective, non-competitive EAAT1 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (3) Frequently bought together
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Biological Data

Biological description

UCPH-101 is a potent, selective, non-competitive inhibitor of the EAAT1 (Excitatory Amino Acid Transporter 1) glutamate transporter (IC50 = 660 nM). UCPH-101 shows >400-fold selectivity for EAAT1 over EAAT2 and EAAT3 and shows no inhibitory activity at EAAT4 and EAAT5 in a patch-clamp electrophysiology assay (in which final concentration was up to 10 μM). UCPH-102 which is blood brain barrier permeable is now also available.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene- 3-carbonitrile
Molecular Weight 422.48
Chemical structure UCPH 101 [1118460-77-7] Chemical Structure
Molecular Formula C27H22N2O3
CAS Number 1118460-77-7
PubChem identifier 25223366
SMILES COC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC5=CC=CC=C54)N)C#N
Source Synthetic
InChi InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3
InChiKey YBMGNDPBARCLFT-UHFFFAOYSA-N
Appearance White solid

References for UCPH 101

References are publications that support the biological activity of the product

  • Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.

    Abrahamsen B et al (2013) J Neurosci 33(3) : 1068-87.
    Read more (PubMedID: 23325245)

  • Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.

    Huynh TH et al (2012) Bioorg Med Chem 20(23) : 6831-9.
    Read more (PubMedID: 23072958)

  • Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.

    Jensen AA et al (2009) J Med Chem 52(4) : 912-5.
    Read more (PubMedID: 19161278)

3 Item(s)

Publications
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These publications cite the use of UCPH 101 purchased from Hello Bio:

  • Complete but not partial inhibition of glutamate transporters exacerbates cortical excitability in the R6/2 mouse model of Huntington's disease.

    Estrada-Sánchez et al (2018) CNS Neurosci Ther doi: 10.1111/ : cns.13070.
    PubMedID: 30311425

1 Item

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Order: HB0630
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10mg
$155
UCPH-101 is a potent, selective, non-competitive EAAT1 inhibitor
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