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UBP714 ammonium salt

(HB8161)
Publications (1)

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Product overview

Name UBP714 ammonium salt
Alternative names UBP-714, UBP 714
Purity >98%
Description NMDAR PAM which potentiates GluN2A and GluN2B with minimal effects on 2C and 2D.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews Publications (1) References (4) Frequently bought together
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Biological Data

Biological description

NMDAR PAM which potentiates GluN2A and GluN2B NMDAR subunits with minimal effects on GluN2C and GluN2D.

Potentiates NMDAR mediated fEPSPs (field excitatory postsynaptic potentials) but not AMPAR mediated fEPSPs in the CA1 region of the hippocampus. Potentiates sub-maximal LTP and reduces LTD.

Solubility & Handling

Solubility overview Soluble in water (50 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 6-Bromo-4-methyl-2-oxo-2H-1-benzopyran-3-carboxylic acid ammonium salt
Molecular Weight 283.07
Chemical structure UBP 714 [773109-55-0] Chemical Structure
Molecular Formula C11H7BrO4.NH3
CAS Number 773109-55-0
PubChem identifier 56650009
SMILES CC1=C(C(=O)OC2=C1C=C(C=C2)Br)C(=O)O
InChi InChI=1S/C11H7BrO4/c1-5-7-4-6(12)2-3-8(7)16-11(15)9(5)10(13)14/h2-4H,1H3,(H,13,14)
InChiKey BWBWVUJRXNIUMA-UHFFFAOYSA-N
Appearance Off-white solid

References for UBP714 ammonium salt

References are publications that support the biological activity of the product

  • Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

    France et al (2022) Neuropharmacology : 202:108840
    Read more (PubMedID: 34678377)

  • Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action

    Burnell et al (2019) J Med Chem. 62(1) : 3-23
    Read more (PubMedID: 29446949)

  • Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

    Sapkota et al (2017) Neuropharmacology 125: : 64-79
    Read more (PubMedID: 28709671)

  • Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors

    Irvine et al (2012) Neurochem Int. 61(4) : 593-600
    Read more (PubMedID: 22265875)

4 Item(s)

Publications
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These publications cite the use of UBP714 ammonium salt purchased from Hello Bio:

  • HDAC4 Inhibits NMDA Receptor-Mediated Stimulation of Neurogranin Expression

    de Andres et al (2024) bioRxiv

1 Item

Related Products
Grouped product items
Order: HB8161
Pack PriceQty
10mg
$187
50mg
$711
NMDAR PAM which potentiates GluN2A and GluN2B with minimal effects on 2C and 2D.
Shipping Info

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