Product overview

Name UBP714 ammonium salt
Alternative names UBP-714, UBP 714
Purity >98%
Description NMDAR PAM which potentiates GluN2A and GluN2B with minimal effects on 2C and 2D.
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Biological Data

Biological description

NMDAR PAM which potentiates GluN2A and GluN2B NMDAR subunits with minimal effects on GluN2C and GluN2D.

Potentiates NMDAR mediated fEPSPs (field excitatory postsynaptic potentials) but not AMPAR mediated fEPSPs in the CA1 region of the hippocampus. Potentiates sub-maximal LTP and reduces LTD.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >98%
Chemical name 6-Bromo-4-methyl-2-oxo-2H-1-benzopyran-3-carboxylic acid ammonium salt
Molecular Weight 283.07
Chemical structure UBP 714 [773109-55-0] Chemical Structure
Molecular Formula C11H7BrO4.NH3
CAS Number 773109-55-0
PubChem identifier 56650009
InChi InChI=1S/C11H7BrO4/c1-5-7-4-6(12)2-3-8(7)16-11(15)9(5)10(13)14/h2-4H,1H3,(H,13,14)
Appearance Off-white solid

References for UBP714 ammonium salt

References are publications that support the biological activity of the product
  • Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

    France et al (2022) Neuropharmacology : 202:108840
  • Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action

    Burnell et al (2019) J Med Chem. 62(1) : 3-23
  • Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

    Sapkota et al (2017) Neuropharmacology 125: : 64-79
  • Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors

    Irvine et al (2012) Neurochem Int. 61(4) : 593-600

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