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Biological Data Biological description NMDAR PAM which potentiates GluN2A and GluN2B NMDAR subunits with minimal effects on GluN2C and GluN2D.
Potentiates NMDAR mediated fEPSPs (field excitatory postsynaptic potentials) but not AMPAR mediated fEPSPs in the CA1 region of the hippocampus. Potentiates sub-maximal LTP and reduces LTD.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in water (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name 6-Bromo-4-methyl-2-oxo-2H-1-benzopyran-3-carboxylic acid ammonium salt
Chemical structure
Molecular Formula C11 H7 BrO4 .NH3
PubChem identifier 56650009
SMILES CC1=C(C(=O)OC2=C1C=C(C=C2)Br)C(=O)O
InChi InChI=1S/C11H7BrO4/c1-5-7-4-6(12)2-3-8(7)16-11(15)9(5)10(13)14/h2-4H,1H3,(H,13,14)
InChiKey BWBWVUJRXNIUMA-UHFFFAOYSA-N
Appearance Off-white solid
References for UBP714 ammonium salt References are publications that support the biological activity of the product
Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators France et al (2022) Neuropharmacology : 202:108840 Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action Burnell et al (2019) J Med Chem. 62(1) : 3-23 Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives Sapkota et al (2017) Neuropharmacology 125: : 64-79 Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors Irvine et al (2012) Neurochem Int. 61(4) : 593-600
Publications
These publications cite the use of UBP714 ammonium salt purchased from Hello Bio:
HDAC4 Inhibits NMDA Receptor-Mediated Stimulation of Neurogranin Expression de Andres et al (2024) bioRxiv
NMDAR PAM which potentiates GluN2A and GluN2B with minimal effects on 2C and 2D.
![UBP 714 [773109-55-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb8161.png "UBP 714 [773109-55-0]")
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