Product overview

Name 2-APB
Description IP3 receptor and store-operated channels (SOC) channel antagonist
Alternative names 2-aminoethoxydiphenyl borate
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Biological Data

Biological description

2-APB is a membrane permeable IP3 (inositol 1,4,5-trisphosphate) receptor antagonist (IC50 = 42µM) and store-operated Ca2+ channel (SOC) antagonist.


2-APB also blocks SERCA (IC50 = 91µM) and modulates some TRP channels (inhibits TRPC1, TRPC3 and TRPC5, activates TRPV1, TRPV2 and TRPV3 and shows dual activity on TRPM7 channels).


2-APB is an effector of store-operated Ca2+ entry (SOCE) which potentiates store-operated Ca2+ entry at 1-5 µM and inhibits it at >30 µM.


2-APB has also been shown to increase excitability in pyramidal neurons.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) and ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2-Aminoethoxydiphenylborane
Molecular Weight 225.1
Chemical structure 2-APB [524-95-8] Chemical Structure
Molecular Formula C14H16BNO
CAS Number 524-95-8
PubChem identifier 1598
SMILES NCCOB(C1=CC=CC=C1)C1=CC=CC=C1
InChi InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChiKey BLZVCIGGICSWIG-UHFFFAOYSA-N
MDL number MFCD00014823
Appearance White solid

References for 2-APB

References are publications that support the biological activity of the product
  • Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12.

    Takahashi et al (2014) Exp Cell Res 232(2) : 337-45
  • 2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons.

    Hagenston et al (2009) Cell Calcium 45(3) : 310-7
  • Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).

    Togashi et al (2008) Br J Pharmacol 153(6) : 1324-30
  • 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.

    Bootman et al (2002) FASEB J 16(10) : 1145-50
  • 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.

    Maruyama et al (1997) J Biochem 122(3) : 498-505