Product overview

Name Thioflavin S (ThioS)
Biological description

Fluorescent amyloid β dye with β-sheet binding properties which is commonly used to observe amyloid plaque accumulation and to detect amyloid pathology.

Alternative names ThioS, ThS
Description

Fluorescent amyloid β dye, used to detect amyloid pathology.

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Biological Data

Application notes

Please see our Amyloid Beta Protocol

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

CAS Number 1326-12-1 (Mixture of compounds)

References for Thioflavin S (ThioS)

References are publications that support the biological activity of the product
  • Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model.

    Shin J et al (2021) Scientific reports 11 : 1617
  • Thioflavin-S staining coupled to flow cytometry. A screening tool to detect in vivo protein aggregation.

    Espargaró A et al (2012) Molecular bioSystems 8 : 2839-44
  • Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.

    Bussière T et al (2004) The American journal of pathology 165 : 987-95

3 Item(s)