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Orexin B (human)

(HB5323)
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Product overview

Name Orexin B (human)
Biological description

Overview

Excitatory neuropeptide at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors respectively).

Orexin-B is synthesized in the lateral hypothalamus and perifornical area. Orexin B is a linear neuropeptide with 28 amino acids.

Uses and applications

Orexin B is involved in a wide range of biological functions (feeding behavior, sleep-wake cycle, energy metabolism etc.). Also shows neuroprotective activity for dopaminergic neurons in rat midbrain cultures.
Purity >95%
Description Excitatory neuropeptide at orexin OX1/OX2 receptors
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name RSGPPGLQGRLQRLLQASGNHAAGILTM (Met-28 = C-terminal amide)
Molecular Weight 2899.38
Chemical structure Orexin B (human) [205640-91-1] Chemical Structure
Molecular Formula C123H212N44O35S
Sequence (one letter) RSGPPGLQGRLQRLLQASGNHAAGILTM
Sequence (three letter) Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met
Modifications Met-28 = C-terminal amide
CAS Number 205640-91-1
PubChem identifier 90479794
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)N
InChiKey DHBREICAXZPFDD-WMQZXSDYSA-N
Protein length 28

References for Orexin B (human)

References are publications that support the biological activity of the product

  • Orexin System: The Key for a Healthy Life.

    Chieffi et al (2017) Front Physiol 31;8 : 357
    Read more (PubMedID: 28620314)

  • The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.

    Guerreiro et al (2015) Mol Phamacol. 87(3) : 525-32
    Read more (PubMedID: 25552485)

  • Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system.

    Tsujino et al (2009) Pharmacol Rev 61(2) : 162-76
    Read more (PubMedID: 19549926)

3 Item(s)

Related Products
Grouped product items
Order: HB5323
Pack PriceQty
500μg
$147
Excitatory neuropeptide at orexin OX1/OX2 receptors
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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