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Orexin B (human)

(HB5323)
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Product overview

Name Orexin B (human)
Biological description

Overview

Excitatory neuropeptide at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors respectively).

Orexin-B is synthesized in the lateral hypothalamus and perifornical area. Orexin B is a linear neuropeptide with 28 amino acids.

Uses and applications

Orexin B is involved in a wide range of biological functions (feeding behavior, sleep-wake cycle, energy metabolism etc.). Also shows neuroprotective activity for dopaminergic neurons in rat midbrain cultures.
Purity >95%
Description Excitatory neuropeptide at orexin OX1/OX2 receptors
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name RSGPPGLQGRLQRLLQASGNHAAGILTM (Met-28 = C-terminal amide)
Molecular Weight 2899.38
Chemical structure Orexin B (human) [205640-91-1] Chemical Structure
Molecular Formula C123H212N44O35S
Sequence (one letter) RSGPPGLQGRLQRLLQASGNHAAGILTM
Sequence (three letter) Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met
Modifications Met-28 = C-terminal amide
CAS Number 205640-91-1
PubChem identifier 90479794
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)N
InChiKey DHBREICAXZPFDD-WMQZXSDYSA-N
Protein length 28

References for Orexin B (human)

References are publications that support the biological activity of the product

  • Orexin System: The Key for a Healthy Life.

    Chieffi et al (2017) Front Physiol 31;8 : 357
    Read more (PubMedID: 28620314)

  • The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.

    Guerreiro et al (2015) Mol Phamacol. 87(3) : 525-32
    Read more (PubMedID: 25552485)

  • Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system.

    Tsujino et al (2009) Pharmacol Rev 61(2) : 162-76
    Read more (PubMedID: 19549926)

3 Item(s)

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Order: HB5323
Pack PriceQty
500μg
$141
Excitatory neuropeptide at orexin OX1/OX2 receptors
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