Selective Dopamine D1-D2 heteromer antagonist which occludes the interaction site between the two receptors to inhibit D1-D2 heteromer expression and function. Alleviates behavioural despair symptoms and exerts antidepressant-like effects. Active in vivo.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in PBS (1 mg/ml), and in DMSO
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism.
Hasbi A et al (2014) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 : 4806-20
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