Selective Dopamine D1-D2 heteromer antagonist which occludes the interaction site between the two receptors to inhibit D1-D2 heteromer expression and function. Alleviates behavioural despair symptoms and exerts antidepressant-like effects. Active in vivo.
Solubility & Handling
Solubility overview
Soluble in PBS (1 mg/ml), and in DMSO
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism.
Hasbi A et al (2014) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 : 4806-20
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