Product overview

Name Tamoxifen Citrate
Description Estrogen receptor antagonist/ partial agonist. May be used in genome engineering (e.g. CreER/ CRISPR-Cas9). Citrate salt.
Alternative names TAM
Purity >98%
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Biological Data

Biological description

Citrate salt of Tamoxifen, which is an estrogen receptor antagonist and partial agonist. It is also a potent chloride channel HSV-1 inhibitor and is blood brain barrier permeable.

Tamoxifen inhibits tumor growth and induces apoptosis in breast cancer cells. It also selectively inhibits sterol biosynthesis (IC50 = 1000 nM) and shows neuroprotective potential.

It is used in gene editing in which tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation and lineage tracing studies in mice.

It can also switch on the inducible CRISPR-Cas9 system (iCas).

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in Dimethylsulfoxide (100mM), and in ethanol (5 mM with warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Molecular Weight 563.7
Chemical structure Tamoxifen Citrate  [54965-24-1] Chemical Structure
Molecular Formula C32H37NO8
CAS Number 54965-24-1
PubChem identifier 2733525
SMILES CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChi InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
InChiKey FQZYTYWMLGAPFJ-OQKDUQJOSA-N
MDL number MFCD00058321
Appearance White solid

References for Tamoxifen Citrate

References are publications that support the biological activity of the product
  • A Chemical-Inducible CRISPR-Cas9 System for Rapid Control of Genome Editing

    Liu et al (2016) Nat Chem Biol. 12(11) : 980-987
  • Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.

    Zheng K et al (2014) Biochem Biophys Res Commun 446(4) : 990-6.
  • Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.

    Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73.
  • Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.

    Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8.
  • Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.

    Paul R et al (1998) J Pharmacol Exp Ther 285(3) : 1296-302.