Product overview
| Name | Tamoxifen Citrate |
| Description | Estrogen receptor antagonist/ partial agonist. May be used in genome engineering (e.g. CreER/ CRISPR-Cas9). Citrate salt. |
| Alternative names | TAM |
| Purity | >98% |
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Biological Data
| Biological description | Citrate salt of Tamoxifen, which is an estrogen receptor antagonist and partial agonist. It is also a potent chloride channel HSV-1 inhibitor and is blood brain barrier permeable. Tamoxifen inhibits tumor growth and induces apoptosis in breast cancer cells. It also selectively inhibits sterol biosynthesis (IC50 = 1000 nM) and shows neuroprotective potential. It is used in gene editing in which tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation and lineage tracing studies in mice.
It can also switch on the inducible CRISPR-Cas9 system (iCas). |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in Dimethylsulfoxide (100mM), and in ethanol (5 mM with warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate |
| Molecular Weight | 563.7 |
| Chemical structure | ![Tamoxifen Citrate [54965-24-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0602.png "Tamoxifen Citrate [54965-24-1]") |
| Molecular Formula | C32H37NO8 |
| CAS Number | 54965-24-1 |
| PubChem identifier | 2733525 |
| SMILES | CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
| InChi | InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-; |
| InChiKey | FQZYTYWMLGAPFJ-OQKDUQJOSA-N |
| MDL number | MFCD00058321 |
| Appearance | White solid |
References for Tamoxifen Citrate
References are publications that support the biological activity of the product
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A Chemical-Inducible CRISPR-Cas9 System for Rapid Control of Genome Editing
Liu et al (2016) Nat Chem Biol. 12(11) : 980-987 -
Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.
Zheng K et al (2014) Biochem Biophys Res Commun 446(4) : 990-6. -
Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.
Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73. -
Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.
Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8. -
Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.
Paul R et al (1998) J Pharmacol Exp Ther 285(3) : 1296-302.
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