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Images Spermine product vial image | Hello Bio
Spermine product vial image | Hello Bio Biological Data Biological description Endogenous polyamine NMDA receptor activity modulator with agonist and antagonist actions. Binds at the polyamine site. Sensitizes ASIC1a channels to acidosis and exacerbates ischemic injury of neurones.
Solubility & Handling Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N 1 ,N 4 -Bis(3-aminopropyl)butane-1,4-diamine
Chemical structure
Molecular Formula C10 H26 N4
InChi InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChiKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
References for Spermine References are publications that support the biological activity of the product
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. Duan B et al (2011) J Neurosci 31(6) : 2101-12. Interactions of polyamines with ion channels. Williams K (1997) Biochem J 325 ( Pt 2) : 289-97. Polyamines modulate the neurotoxic effects of NMDA in vivo. Munir M et al (1993) Brain Res 616(1-2) : 163-70.
Publications
These publications cite the use of Spermine purchased from Hello Bio:
Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors Yi F et al (2019) J Physiol 597(22) : 5495-5514 Properties of triheteromeric NMDA receptors containing two distinct GluN1 isoforms. Yi et al (2018) Mol Pharmacol pii: mol.117.111427 : /mol.117.111427. [Epub ahead of
NMDA receptor modulator / ASIC1a channel sensitizer
![Spermine [71-44-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0588.png "Spermine [71-44-3]")
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