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Spermine

(HB0588)
Publications (2)
Technical documents: SDS Datasheet
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Product overview

Name Spermine
Purity >99%
Description NMDA receptor modulator / ASIC1a channel sensitizer
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews Publications (2) References (3) Frequently bought together
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Spermine product vial image | Hello Bio
Spermine product vial image | Hello Bio

Spermine product vial image | Hello Bio

Spermine product vial image | Hello Bio

Biological Data

Biological description Endogenous polyamine NMDA receptor activity modulator with agonist and antagonist actions. Binds at the polyamine site. Sensitizes ASIC1a channels to acidosis and exacerbates ischemic injury of neurones.

Solubility & Handling

Solubility overview Soluble in water (100mM)
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N1,N4-Bis(3-aminopropyl)butane-1,4-diamine
Molecular Weight 202.34
Chemical structure Spermine [71-44-3] Chemical Structure
Molecular Formula C10H26N4
CAS Number 71-44-3
PubChem identifier 1103
SMILES NCCCNCCCCNCCCN
InChi InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChiKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
MDL number MFCD00008215

References for Spermine

References are publications that support the biological activity of the product

  • Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

    Duan B et al (2011) J Neurosci 31(6) : 2101-12.
    Read more (PubMedID: 21307247)

  • Interactions of polyamines with ion channels.

    Williams K (1997) Biochem J 325 ( Pt 2) : 289-97.
    Read more (PubMedID: 9230104)

  • Polyamines modulate the neurotoxic effects of NMDA in vivo.

    Munir M et al (1993) Brain Res 616(1-2) : 163-70.
    Read more (PubMedID: 8358608)

3 Item(s)

Publications
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These publications cite the use of Spermine purchased from Hello Bio:

  • Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

    Yi F et al (2019) J Physiol 597(22) : 5495-5514
    PubMedID: 31541561

  • Properties of triheteromeric NMDA receptors containing two distinct GluN1 isoforms.

    Yi et al (2018) Mol Pharmacol pii: mol.117.111427 : /mol.117.111427. [Epub ahead of
    PubMedID: 29483146

2 Item(s)

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Grouped product items
Order: HB0588
Pack PriceQty
100mg
$74
NMDA receptor modulator / ASIC1a channel sensitizer
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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