(S)-3,4-DCPG

Name: (S)-3,4-DCPG
Brand: Hello Bio
SKU: HB0044
Price: 34 USD
Availability: InStock

(HB0044)

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Technical documents: SDS Datasheet

Product overview

Name

(S)-3,4-DCPG

Alternative names

(S)-3,4-Dicarboxyphenylglycine; UBP1109

Purity

>95%

Description

Potent, selective mGlu_8a agonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) References (4) Frequently bought together

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Biological Data

Biological description

Potent and selective mGlu_8a receptor agonist (EC₅₀ = 31 nM). Selective for mGlu_8a receptor over mGlu_1-7 receptors (EC₅₀ / IC₅₀ values are >3.5 µM). Shows neuroprotective, anti-cataleptic and anticonvulsant actions.

Solubility & Handling

Storage instructions

Room temperature (desiccate)

Solubility overview

Soluble in water (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>95%

Chemical name

(S)-3,4-Dicarboxyphenylglycine

Molecular Weight

239.18

Chemical structure

Molecular Formula

C₁₀H₉NO₆

CAS Number

201730-11-2

PubChem identifier

16062593

SMILES

OC(=O)c1cc(ccc1C(=O)O)[C@H](N)C(=O)O

InChi

InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

InChiKey

IJVMOGKBEVRBPP-ZETCQYMHSA-N

Technical guides

Metabotropic glutamate receptor (mGluR) mini-review

mGlu receptor (mGluR) associated proteins mini-review

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for (S)-3,4-DCPG

References are publications that support the biological activity of the product

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.
Jantas D et al (2014) Neuropharmacology 83 : 36-53.
Read more (PubMedID: 24713472)
The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.
Johnson KA et al (2013) Neuropharmacology 66 : 187-95.
Read more (PubMedID: 22546615)
Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.
Folbergrová J et al (2008) Neuropharmacology 54(4) : 665-75.
Read more (PubMedID: 18191956)
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Thomas NK et al (2001) Neuropharmacology 40(3) : 311-8.
Read more (PubMedID: 11166323)

Grouped product items
Order: HB0044
Pack	Price	Qty
1mg	$34
5mg	$131
10mg	$215
50mg	$835

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Potent, selective mGlu_8a agonist

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(S)-3,4-DCPG

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for (S)-3,4-DCPG

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.

The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

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(S)-3,4-DCPG

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for (S)-3,4-DCPG

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.

The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

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