Potent and selective mGlu8a receptor agonist (EC50 = 31 nM). Selective for mGlu8a receptor over mGlu1-7 receptors (EC50 / IC50 values are >3.5 µM). Shows neuroprotective, anti-cataleptic and anticonvulsant actions.
Solubility & Handling
Solubility overview
Soluble in water (100mM)
Storage instructions
Room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References are publications that support the biological activity of the product
Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.
Jantas D et al (2014) Neuropharmacology 83 : 36-53.
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Thomas NK et al (2001) Neuropharmacology 40(3) : 311-8.
![(S)-3,4-DCPG [201730-11-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0044.png "(S)-3,4-DCPG [201730-11-2]")
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