Product overview

Name (S)-3,4-DCPG
Alternative names (S)-3,4-Dicarboxyphenylglycine; UBP1109
Purity >95%
Description Potent, selective mGlu8a agonist
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Biological Data

Biological description Potent and selective mGlu8a receptor agonist (EC50 = 31 nM). Selective for mGlu8a receptor over mGlu1-7 receptors (EC50 / IC50 values are >3.5 µM). Shows neuroprotective, anti-cataleptic and anticonvulsant actions.

Solubility & Handling

Storage instructions

Room temperature (desiccate)

Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name (S)-3,4-Dicarboxyphenylglycine
Molecular Weight 239.18
Chemical structure (S)-3,4-DCPG  [201730-11-2] Chemical Structure
Molecular Formula C10H9NO6
CAS Number 201730-11-2
PubChem identifier 16062593
SMILES OC(=O)c1cc(ccc1C(=O)O)[C@H](N)C(=O)O
InChi InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

References for (S)-3,4-DCPG

References are publications that support the biological activity of the product
  • Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.

    Jantas D et al (2014) Neuropharmacology 83 : 36-53.
  • The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

    Johnson KA et al (2013) Neuropharmacology 66 : 187-95.
  • Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.

    Folbergrová J et al (2008) Neuropharmacology 54(4) : 665-75.
  • (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

    Thomas NK et al (2001) Neuropharmacology 40(3) : 311-8.

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