Product overview

Name CPPG
Purity >98%
Description Potent group III mGluR antagonist
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Biological Data

Biological description Potent mGlu receptor antagonist. Shows 20-fold selectivity for group III compared to group II mGlu receptors (IC50 values are 2.2 and 46.3 nM respectively). Less potent antagonist at group I mGlu receptors.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (RS)-α-Cyclopropyl-4-phosphonophenyl glycine
Molecular Weight 271.21
Chemical structure CPPG  [183364-82-1] Chemical Structure
Molecular Formula C11H14NO5P
CAS Number 183364-82-1
PubChem identifier 2878
SMILES NC(C2CC2)(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1
InChiKey IGODGTDUQSMDQU-UHFFFAOYSA-N

References for CPPG

References are publications that support the biological activity of the product
  • Antagonism of metabotropic glutamate receptor 4 receptors by (RS)-alpha-cyclopropyl-4-phosphonophenylglycine alters the taste of amino acids in rats.

    Eschle BK et al (2009) Neuroscience 163(4) : 1292-301.
  • Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.

    Jane DE et al (1996) Neuropharmacology 35(8) : 1029-35.
  • The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist.

    Toms NJ et al (1996) Br J Pharmacol 119(5) : 851-4.

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