Product overview

Name Rotenone
Purity >95%
Description Mitochondrial Complex I Inhibitor. Induces mitochondrial dysfunction.
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Biological Data

Biological description

Mitochondrial Complex I Inhibitor which impairs mitochondrial respiration by inhibiting to induce ATP depletion, mROS production and loss of mitochondrial membrane potential.

It is commonly used to experimentally induce mitochondrial dysfunction and also used to induce Parkinsonian animal disease models.

Also induces proteasome inhibition.

Cell permeable and brain penetrant.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Molecular Weight 394.42
Chemical structure Rotenone [83-79-4] Chemical Structure
Molecular Formula C23H22O6
CAS Number 83-79-4
PubChem identifier 6758
SMILES CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC
InChi InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
MDL number MFCD09025614
Appearance Off-white solid

References for Rotenone

References are publications that support the biological activity of the product
  • Mechanisms of Rotenone-Induced Proteasome Inhibition

    Chou et al (367-72) Neurotoxicology : 31(4)
  • Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

    Heinz et al (2017) Sci Rep. : 7,45465
  • Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

    Hee Won et al (2015) J Biol CHem 290(45) : 27425-37

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