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Biological Data Biological description FCCP is an protonophore which is widely used to investigate the role of mitochondria in cellular function.
FCCP also induces apoptosis.
CCCP is also available.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Chemical structure
Molecular Formula C10 H5 F3 N4 O
SMILES C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
InChi InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
InChiKey BMZRVOVNUMQTIN-UHFFFAOYSA-N
References for FCCP References are publications that support the biological activity of the product
Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells. MS et al (2010) Arch Biochem Biophys 495(2) : 152-8 Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Brennan et al (2006) Cardiovasc Res. 72(2) : 313-21 FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells. Park et al (2002) Pflugers Arch 443(3) : 344-52
Potent uncoupler of mitochondrial oxidative phosphorylation.
![FCCP [370-86-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2903_1.png "FCCP [370-86-5]")
