Product overview

Name Oligomycin A
Purity >98%
Description Inhibitor of mitochondrial function
Write Your Own Review
You're reviewing:Oligomycin A
Rate this item:

Biological Data

Biological description

Inhibitor of mitochondrial function which blocks the proton channel of mitochondrial ATP synthase to block oxidative phosphorylation and inhibit the electron transport chain.

Anti-tumor antibiotic.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Molecular Weight 791.06
Molecular Formula C45H74O11
CAS Number 579-13-5
PubChem identifier 5281899
SMILES CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
InChiKey MNULEGDCPYONBU-MQCNKYSOSA-N
MDL number MFCD00065705
Appearance White to off-white

References for Oligomycin A

References are publications that support the biological activity of the product
  • Oligomycin A-induced Inhibition of Mitochondrial ATP-synthase Activity Suppresses Boar Sperm Motility and in Vitro Capacitation Achievement Without Modifying Overall Sperm Energy Levels

    Lluch et al (2014) Reprod Fertil Dev 26(6) : 883-97
  • Assessing Mitochondrial Dysfunction in Cells

    Brand et al (2011) Biochem J 435(2) : 297-312
  • Mechanism of Inhibition of Mitochondrial Adenosine Triphosphatase by Dicyclohexylcarbodiimide and Oligomycin: Relationship to ATP Synthesis

    Penefsky, (1985) Comparative Study 82(6) : 1589-93

3 Item(s)