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Biological Data
| Application notes | ED50 = <50ng/ml (determined by a cell proliferation assay using serum free human MCF-7 cells), corresponding to a specific activity of >2.0×104 IU/mg |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution |
| Handling |
- Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
- Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
- Freeze-thaw cycles should be prevented.
|
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Appearance | White lyophilized powder (sterile filtered & freeze-dried) |
| Formulation | Lyophilized from a 0.2μm filtered solution in PBS (pH 7.4) |
References for Recombinant human Neuregulin-1 beta 2 protein
References are publications that support the biological activity of the product
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Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
Bian Y et al (2009) Am J Physiol Heart Circ Physiol 297(6) : H1974-83 -
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei L et al (2008) Nat Rev Neurosci 9(6) : 437-52 -
Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
Harrison PJ et al (2006) Biol Psychiatry 60(2) : 132-40
Growth factor implicated in various nervous system functions.
Understanding purity and quality - a guide for life scientists
