Recombinant human Neuregulin-1-B1 / NRG1-B1 protein

Technical documents: Datasheet

Product overview

Name Recombinant human Neuregulin-1-B1 / NRG1-B1 protein
Biological description

Growth factor which activates the ErB2 receptor and is implicated in various nervous system functions and is also involved in many cellular processes.

Alternative names NRG1 B1 Human, Neuregulin-1, Heregulin-b1, NRG1-B1, NRG1 B1.
Purity >97%
Description Growth factor implicated in various nervous system functions.
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Biological Data

Application notes ED50 = <0.5ng/ml (determined by dose-dependent stimulation of human MCF-7 cells proliferation), corresponding to a specific activity of >2.0×106 units/mg

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >97%
Source E. Coli.
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered solution in PBS, pH 7.4 and 5% trehalose

References for Recombinant human Neuregulin-1-B1 / NRG1-B1 protein

References are publications that support the biological activity of the product
  • Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins

    Bian Y et al (2009) Am J Physiol Heart Circ Physiol 297(6) : H1974-83
  • Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

    Mei L et al (2008) Nat Rev Neurosci 9(6) : 437-52
  • Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology

    Harrison PJ et al (2006) Biol Psychiatry 60(2) : 132-40

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