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Biological Data Biological description Potent competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Chemical structure
Molecular Formula C8 H15 N2 O5 P
PubChem identifier 6435801
SMILES C1CN(C[C@@H](N1)C(=O)O)C/C=C/P(=O)(O)O
InChi InChI=1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1
InChiKey VZXMZMJSGLFKQI-ABVWVHJUSA-N
References for (R )-CPPene (SDZ EAA 494) References are publications that support the biological activity of the product
The Excitatory Amino Acid Antagonist D-CPP-ene (SDZ EAA-494) in Patients With Epilepsy Sveinbjornsdottir et al (1993) Epilepsy Res. 16(2) : 165-74 Evaluation of a Competitive NMDA Antagonist (D-CPPene) in Feline Focal Cerebral Ischemia Chen et al (1991) Ann Neurol. 30(1) : 62-70 D-CPP-ene (SDZ EAA 494), a Potent and Competitive N-methyl-D-aspartate (NMDA) Antagonist: Effect on Spontaneous Activity and NMDA-induced Depolarizations in the Rat Neocortical Slice Preparation, Compared With Other CPP Derivatives and MK-801 Lowe et al (1990) Neurosci Lett. 113(3) : 315-21
Potent competitive NMDA antagonist
![(R)-CPPene [117414-74-1 ] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0023_2.png "(R)-CPPene [117414-74-1 ]")
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