Product overview

Name PS-341 [Bortezomib]
Description Highly potent, selective, reversible and cell permeable proteasome inhibitor
Purity >98%
Write Your Own Review
You're reviewing:PS-341 [Bortezomib]
Rate this item:

Images

PS-341 [Bortezomib] product vial image | Hello Bio

Biological Data

Biological description Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Anticancer compound. Inhibits proliferation and migration of several tumor cell lines with nanomolar potency. Apoptosis inducer.

Solubility & Handling

Storage instructions +4°C
Solubility overview DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Molecular Weight 384.2
Molecular Formula C19H25BN4O4
CAS Number 179324-69-7
PubChem identifier 387447
SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c2cnccn2)B(O)O
InChiKey GXJABQQUPOEUTA-RDJZCZTQSA-N
Appearance White solid

References for PS-341 [Bortezomib]

References are publications that support the biological activity of the product
  • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells

    Hideshima et al (3071-6.) Cancer Res. : 61(7)
  • Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells

    Fribley et al (2004) Mol Cell Biol 24(22) : 9695-704.
  • Development of the proteasome inhibitor PS-341

    Adams et al (2002) Oncologist 7(1) : 9-16.