Product overview
| Name | MG132 |
| Description | Potent, cell-permeable proteasome inhibitor. Calpain inhibitor. Apoptosis inducer. |
| Alternative names | Z-LLL-al, Z-Leu-Leu-Leu-CHO |
| Purity | >95% |
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Biological Data
| Biological description | MG-132 is a potent, cell-permeable proteasome inhibitor (IC50 = 100 nM) which blocks the proteolytic activity of the 26S proteasome complex. It induces cell cycle arrest and triggers apoptosis to inhibit cell growth.
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Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Molecular Weight | 475.62 |
| Chemical structure | ![MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4135_1.png "MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ]") |
| Molecular Formula | C26H41N3O5 |
| CAS Number | 133407-82-6 |
| PubChem identifier | 462382 |
| SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
| Source | Synthetic |
| InChi | InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1 |
| InChiKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
| MDL number | MFCD00674886 |
| Appearance | White solid |
References for MG132
References are publications that support the biological activity of the product
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The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.
Han et al (2009) Oncol Rep 22(1) : 215-21 -
Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination.
Banerjeet and Liefshitz (2001) Anticancer Res 3941-7 : 21(6A) -
Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.
Tsubuki et al (1996) J Biochem 119(3) : 572-6
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