Product overview

Name MG132
Description Potent, cell-permeable proteasome inhibitor. Calpain inhibitor. Apoptosis inducer.
Alternative names Z-LLL-al, Z-Leu-Leu-Leu-CHO
Purity >95%
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Biological Data

Biological description

MG-132 is a potent, cell-permeable proteasome inhibitor (IC50 = 100 nM) which blocks the proteolytic activity of the 26S proteasome complex. It induces cell cycle arrest and triggers apoptosis to inhibit cell growth.


Shows anti-cancer activity in vivo and is also calpain inhibitor.


This is the (S),(S),(S)- stereoisomer.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM) and in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Molecular Weight 475.62
Chemical structure MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ] Chemical Structure
Molecular Formula C26H41N3O5
CAS Number 133407-82-6
PubChem identifier 462382
SMILES CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Source Synthetic
InChi InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChiKey TZYWCYJVHRLUCT-VABKMULXSA-N
MDL number MFCD00674886
Appearance White solid

References for MG132

References are publications that support the biological activity of the product
  • The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.

    Han et al (2009) Oncol Rep 22(1) : 215-21
  • Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination.

    Banerjeet and Liefshitz (2001) Anticancer Res 3941-7 : 21(6A)
  • Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.

    Tsubuki et al (1996) J Biochem 119(3) : 572-6