PP 2

Name: PP 2
SKU: HB1335
Price: 66 USD
Availability: InStock

(HB1335)

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Technical documents: SDS Datasheet

Product overview

Name

PP 2

Purity

>99%

Description

Potent, selective Src-family tyrosine kinase inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

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Biological Data

Biological description

Potent and selective Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC₅₀ values are 4 and 5 nM, 0.48, >50 and > 100 µM respectively). Also inhibits CSK, SAPK2a (p38), SAPK2b (p38β2) and CK1δ. Prevents β-adrenergic stimulation of the cardiac pacemaker. Shows anti-proliferative actions against cancer.

Solubility & Handling

Storage instructions

+4°C (desiccate)

Solubility overview

Soluble in DMSO (25mM, gentle warming) or ethanol (10mM, gentle warming)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Molecular Weight

301.78

Molecular Formula

C₁₅H₁₆ClN₅

CAS Number

172889-27-9

PubChem identifier

4878

SMILES

CC(C)(C)N1N=C(C2=C(N)N=CN=C12)C1=CC=C(Cl)C=C1

InChiKey

PBBRWFOVCUAONR-UHFFFAOYSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for PP 2

References are publications that support the biological activity of the product

PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.
Huang J et al (2014) J Cardiovasc Pharmacol 63(6) : 533-43.
Read more (PubMedID: 24566462)
Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.
Kong L et al (2011) Mol Cell Biochem 348(1-2) : 11-9.
Read more (PubMedID: 21052789)
The specificities of protein kinase inhibitors: an update.
Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
Read more (PubMedID: 12534346)
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.
Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.
Read more (PubMedID: 8557675)

Grouped product items
Order: HB1335
Pack	Price	Qty
1mg	$66
5mg	$140
10mg	$245
25mg	$494

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Potent, selective Src-family tyrosine kinase inhibitor

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PP 2

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for PP 2

PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.

Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.

The specificities of protein kinase inhibitors: an update.

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

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Tell us about your publication!

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PP 2

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for PP 2

PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.

Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.

The specificities of protein kinase inhibitors: an update.

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

About you

Tell us about your publication!

Captcha

About you

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