Product overview

Name Staurosporine
Alternative names AM-2282, STS
Purity >98%
Description Potent, non-specific protein kinase inhibitor. Apoptosis inducer.
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Staurosporine product vial image | Hello Bio

Biological Data

Biological description Potent and non-specific protein kinase inhibitor (IC50 values are 3, 7, 6 and 20 nM at PKC, PKA, p60v-src tyrosine protein kinase and CAMKII respectively). Cell permeable. Induces apoptosis.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (25mg/ml) or DMF (25mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name Antibiotic AM-2282
Molecular Weight 466.53
Chemical structure Staurosporine  [62996-74-1] Chemical Structure
Molecular Formula C28H26N4O3
CAS Number 62996-74-1
PubChem identifier 44259
SMILES CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChiKey HKSZLNNOFSGOKW-FYTWVXJKSA-N

References for Staurosporine

References are publications that support the biological activity of the product
  • Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II.

    Yanagihara N et al (1991) J Neurochem 56(1) : 294-8.
  • Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.

    Rüegg UT et al (1989) Trends Pharmacol Sci 10(6) : 218-20.
  • Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

    Tamaoki T et al (1986) Biochem Biophys Res Commun 135(2) : 397-402.

3 Item(s)

Publications
These publications cite the use of Staurosporine purchased from Hello Bio:
  • Spider venoms and chronic pain–developing novel pharmacological tools from the spider venoms to target P2X4 in microglia

    Bibic et al (2020) UEA : Thesis

1 Item