Product overview

Name Nocodazole
Purity >98%
Description Mitosis inhibitor, widely used as a cell cycle synchronizing agent. Enhances HDR efficiency and increases Cas9-mediated gene editing frequencies.
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Biological Data

Biological description Mitosis inhibitor which which induces microtubule depolymerization in vivo and inhibits tubulin polymerziation. Arrest cell cycle at the G2/M phase. Widely used as a cell cycle synchronizing agent. Enhances homology-directed repair (HDR) efficiency (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Molecular Weight 301.3
Chemical structure Nocodazole [31430-18-9] Chemical Structure
Molecular Formula C14H11N3O3S
CAS Number 31430-18-9
PubChem identifier 4122
Appearance White to off-white solid

References for Nocodazole

References are publications that support the biological activity of the product
  • Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery.

    Lin et al (25497837) Elife 15(3) : e04766
  • Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.

    Webb et al (2004) Int J Biochem Cell Biol 36(12) : 2541-50.
  • Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

    Vasquez et al (1997) Mol Biol Cell 8(6): : 973-85

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