Product overview

Name Nocodazole
Purity >98%
Description Mitosis inhibitor, widely used as a cell cycle synchronizing agent. Enhances HDR efficiency and increases Cas9-mediated gene editing frequencies.
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Biological Data

Biological description Mitosis inhibitor which which induces microtubule depolymerization in vivo and inhibits tubulin polymerziation. Arrest cell cycle at the G2/M phase. Widely used as a cell cycle synchronizing agent. Enhances homology-directed repair (HDR) efficiency (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 301.3
Chemical structure Nocodazole [31430-18-9] Chemical Structure
Molecular Formula C14H11N3O3S
CAS Number 31430-18-9
PubChem identifier 4122
SMILES COC(=O)NC1=NC2=CC(=CC=C2N1)C(=O)C1=CC=CS1
InChiKey KYRVNWMVYQXFEU-UHFFFAOYSA-N
Appearance White to off-white solid

References for Nocodazole

References are publications that support the biological activity of the product
  • Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery.

    Lin et al (25497837) Elife 15(3) : e04766
  • Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.

    Webb et al (2004) Int J Biochem Cell Biol 36(12) : 2541-50.
  • Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

    Vasquez et al (1997) Mol Biol Cell 8(6): : 973-85

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