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Doxorubicin hydrochloride

(HB4183)
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Product overview

Name Doxorubicin hydrochloride
Alternative names Adriamycin, NSC 123127, DOX, DXR
Purity >99%
Description

Antibiotic. DNA topisomerase II inhibitor. Apoptosis inducer.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2) Frequently bought together
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Biological Data

Biological description

Antibiotic and DNA topisomerase II inhibitor.

Intercalates into DNA to inhibit nucleic acid synthesis.

Induces apoptosis and shows antitumor and anti-neoplastic activity

Solubility & Handling

Solubility overview Soluble in DMSO (50 mM) and water (50 mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Molecular Weight 579.99
Molecular Formula C27H29NO11.HCl
CAS Number 25316-40-9
PubChem identifier 443939
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
InChiKey MWWSFMDVAYGXBV-RUELKSSGSA-N
MDL number MFCD00077757
Appearance Orange

References for Doxorubicin hydrochloride

References are publications that support the biological activity of the product

  • Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity.

    Patel et al (1997) Mol Pharmacol 52(4) : 658-66
    Read more (PubMedID: 9380029)

  • Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism.

    Grubb et al (1993) Biochem Pharmacol 46(3) : 357-64
    Read more (PubMedID: 8347161)

2 Item(s)

Related Products
Grouped product items
Order: HB4183
Pack PriceQty
10mg
$123
50mg
$517

Antibiotic. DNA topisomerase II inhibitor. Apoptosis inducer.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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