Product overview

Name Doxorubicin hydrochloride
Alternative names Adriamycin, NSC 123127, DOX, DXR
Purity >99%

Antibiotic. DNA topisomerase II inhibitor. Apoptosis inducer.

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Biological Data

Biological description

Antibiotic and DNA topisomerase II inhibitor.

Intercalates into DNA to inhibit nucleic acid synthesis.

Induces apoptosis and shows antitumor and anti-neoplastic activity

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (50 mM) and water (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Molecular Weight 579.99
Molecular Formula C27H29NO11.HCl
CAS Number 25316-40-9
PubChem identifier 443939
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
MDL number MFCD00077757
Appearance Orange

References for Doxorubicin hydrochloride

References are publications that support the biological activity of the product
  • Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity.

    Patel et al (1997) Mol Pharmacol 52(4) : 658-66
  • Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism.

    Grubb et al (1993) Biochem Pharmacol 46(3) : 357-64

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