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Biological Data Biological description Antibiotic and DNA topisomerase II inhibitor.
Intercalates into DNA to inhibit nucleic acid synthesis.
Induces apoptosis and shows antitumor and anti-neoplastic activity
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (50 mM) and water (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Molecular Formula C27 H29 NO11 .HCl
PubChem identifier 443939
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
InChiKey MWWSFMDVAYGXBV-RUELKSSGSA-N
References for Doxorubicin hydrochloride References are publications that support the biological activity of the product
Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity. Patel et al (1997) Mol Pharmacol 52(4) : 658-66 Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism. Grubb et al (1993) Biochem Pharmacol 46(3) : 357-64
Antibiotic. DNA topisomerase II inhibitor. Apoptosis inducer.
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