Endomorphin-2

(HB2411)

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Product overview

Name Endomorphin-2
Purity >95%
Description Potent, selective μ-opioid receptor agonist
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Biological Data

Biological description Potent, selective μ-opioid receptor agonist (Ki values are 0.69 nM and 9.2 and 5.2 µM at μ, δ and κ receptors respectively). Endogenous peptide. Shows antinociceptive activity.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name Tyr-Pro-Phe-Phe-NH2
Molecular Weight 571.65
Molecular Formula C32H37N5O5
CAS Number 141801-26-5
PubChem identifier 5311081
SMILES C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)N
InChiKey XIJHWXXXIMEHKW-LJWNLINESA-N

References for Endomorphin-2

References are publications that support the biological activity of the product
  • Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.

    Wang et al (2014) PLoS 9 : e103773
  • Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists.

    Horvath (2000) Pharmacol Ther 88 : 437-63
  • A potent and selective endogenous agonist for the mu-opiate receptor.

    Zadina et al (1997) Nature 386 : 499-502

3 Item(s)