Endomorphin-1

(HB2410)

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Product overview

Name Endomorphin-1
Description Potent, selective μ-opioid receptor agonist
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Biological Data

Biological description Potent, selective μ-opioid receptor agonist (Ki values are 360 pM and >1000 nM at μ, δ and κ receptors respectively). Endogenous peptide. Shows >4000 and 15,000-fold selectivity for μ over δ and κ receptors. Shows antinociceptive activity.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Tyr-Pro-Trp-Phe-NH2
Molecular Weight 610.67
Molecular Formula C34H38N6O5
CAS Number 189388-22-5
PubChem identifier 5311080
SMILES C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)N
InChiKey ZEXLJFNSKAHNFH-SYKYGTKKSA-N

References for Endomorphin-1

References are publications that support the biological activity of the product
  • Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.

    Wang et al (2014) PLoS 9 : e103773
  • Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists.

    Horvath (2000) Pharmacol Ther 88 : 437-63
  • A potent and selective endogenous agonist for the mu-opiate receptor.

    Zadina et al (1997) Nature 386 : 499-502

3 Item(s)