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N-Arachidonylglycine (NAGly)

(HB0439)
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Product overview

Name N-Arachidonylglycine (NAGly)
Alternative names NAGly
Description Endogenous GLYT2 inhibitor / Cav3.1 / 3.2 / 3.3 current inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Endogenous GLYT2 inhibitor (IC50 = 3 µM) that displays little activity at GLYT1. Also reversibly inhibits Cav3.1, Cav3.2 and Cav3.3 currents (EC50 values are 1.3 µM, 600 nM and 1.6 µM respectively). Novel insulin secretagogue and natural ligand for orphan G-protein-coupled receptor, GPR18. Displays analgesic properties.

Solubility & Handling

Solubility overview Soluble in ethanol (100mM)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Chemical name N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetrae nyl)glycine
Molecular Weight 361.52
Chemical structure N-Arachidonylglycine (NAGly) [179113-91-8] Chemical Structure
Molecular Formula C22H35NO3
CAS Number 179113-91-8
PubChem identifier 5283389
SMILES O=C(CCC/C=CC/C=CC/C=CC/C=CCCCCC)NCC(=O)O
InChiKey YLEARPUNMCCKMP-DOFZRALJSA-N

References for N-Arachidonylglycine (NAGly)

References are publications that support the biological activity of the product

  • T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

    Barbara G et al (2009) J Neurosci 29(42) : 13106-14.
    Read more (PubMedID: 19846698)

  • Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.

    Edington AR et al (2009) J Biol Chem 284(52) : 36424-30.
    Read more (PubMedID: 19875446)

  • Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

    Kohno M et al (2006) Biochem Biophys Res Commun 347(3) : 827-32.
    Read more (PubMedID: 16844083)

  • Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.

    Ikeda Y et al (2005) Biochem Biophys Res Commun 333(3) : 778-86.
    Read more (PubMedID: 15967412)

4 Item(s)

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Order: HB0439
Pack PriceQty
5mg
$97
25mg
$343
Endogenous GLYT2 inhibitor / Cav3.1 / 3.2 / 3.3 current inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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