Product overview

Name N-Arachidonylglycine (NAGly)
Description Endogenous GLYT2 inhibitor / Cav3.1 / 3.2 / 3.3 current inhibitor
Alternative names NAGly
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Biological Data

Biological description Endogenous GLYT2 inhibitor (IC50 = 3 µM) that displays little activity at GLYT1. Also reversibly inhibits Cav3.1, Cav3.2 and Cav3.3 currents (EC50 values are 1.3 µM, 600 nM and 1.6 µM respectively). Novel insulin secretagogue and natural ligand for orphan G-protein-coupled receptor, GPR18. Displays analgesic properties.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetrae nyl)glycine
Molecular Weight 361.52
Chemical structure N-Arachidonylglycine (NAGly)  [179113-91-8] Chemical Structure
Molecular Formula C22H35NO3
CAS Number 179113-91-8
PubChem identifier 5283389
SMILES O=C(CCC/C=CC/C=CC/C=CC/C=CCCCCC)NCC(=O)O
InChiKey YLEARPUNMCCKMP-DOFZRALJSA-N

References for N-Arachidonylglycine (NAGly)

References are publications that support the biological activity of the product
  • T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

    Barbara G et al (2009) J Neurosci 29(42) : 13106-14.
  • Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.

    Edington AR et al (2009) J Biol Chem 284(52) : 36424-30.
  • Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

    Kohno M et al (2006) Biochem Biophys Res Commun 347(3) : 827-32.
  • Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.

    Ikeda Y et al (2005) Biochem Biophys Res Commun 333(3) : 778-86.

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