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iso-PPADS tetrasodium salt

(HB1951)
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Product overview

Name iso-PPADS tetrasodium salt
Description Non-selective purinergic P2X receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description

iso-PPADS is a non-selective purinergic P2X receptor antagonist (pKi = 6.5).

It potently inhibits P2X1 and P2X3 receptors (IC50 values are 43 and 84 nM respectively). iso-PPADs is more potent than PPADs at P2X1, P2X2, P2X3 and P2Y1 receptors.


iso-PPADS exhibits similarly activity to PPADS.

Solubility & Handling

Solubility overview Soluble in water (100 mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Chemical name Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Molecular Weight 599.3
Chemical structure iso-PPADS [207572-67-6] Chemical Structure
Molecular Formula C14H10N3Na4O12PS2
CAS Number 207572-67-6
PubChem identifier 57369506
SMILES CC1=NC(=NNC2=C(C=CC(=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])C(=C(C1=O)C=O)COP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
Source Synthetic
InChi InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-4-8(31(23,24)25)2-3-12(11)32(26,27)28;;;;/h2-5,16H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;/q;4*+1/p-4
InChiKey MNDLDXSGNAXMPP-UHFFFAOYSA-J
Appearance Orange solid

References for iso-PPADS tetrasodium salt

References are publications that support the biological activity of the product

  • Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors.

    Brown et al (2001) Drug Dev Res. 53(4) : 281-291
    Read more (PubMedID: 27134334)

  • Differentiation by pyridoxal 5-phosphate, PPADS and IsoPPADS between responses mediated by UTP and those evoked by alpha, beta-methylene-ATP on rat sympathetic ganglia.

    Connolly GP (1995) Br J Pharmacol 114(3) : 727-31
    Read more (PubMedID: 7735699)

  • Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens.

    Khakh et al (1994) Eur J Pharmacol 263(3) : 301-9
    Read more (PubMedID: 7843268)

3 Item(s)

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Grouped product items
Order: HB1951
Pack PriceQty
10mg
$76
50mg
$316
Non-selective purinergic P2X receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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