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Biological Data Biological description iso-PPADS is a non-selective purinergic P2X receptor antagonist (pKi = 6.5).
It potently inhibits P2X1 and P2X3 receptors (IC50 values are 43 and 84 nM respectively). iso-PPADs is more potent than PPADs at P2X1 , P2X2 , P2X3 and P2Y1 receptors.
PPADS .
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Chemical structure
Molecular Formula C14 H10 N3 Na4 O12 PS2
PubChem identifier 57369506
SMILES CC1=NC(=NNC2=C(C=CC(=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])C(=C(C1=O)C=O)COP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
InChi InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-4-8(31(23,24)25)2-3-12(11)32(26,27)28;;;;/h2-5,16H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;/q;4*+1/p-4
InChiKey MNDLDXSGNAXMPP-UHFFFAOYSA-J
References for iso-PPADS tetrasodium salt References are publications that support the biological activity of the product
Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Brown et al (2001) Drug Dev Res. 53(4) : 281-291 Differentiation by pyridoxal 5-phosphate, PPADS and IsoPPADS between responses mediated by UTP and those evoked by alpha, beta-methylene-ATP on rat sympathetic ganglia. Connolly GP (1995) Br J Pharmacol 114(3) : 727-31 Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Khakh et al (1994) Eur J Pharmacol 263(3) : 301-9
Non-selective purinergic P2X receptor antagonist
![iso-PPADS [207572-67-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1951_1.png "iso-PPADS [207572-67-6]")
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