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PPADS tetrasodium salt

(HB1950)
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Product overview

Name PPADS tetrasodium salt
Description Non-selective purinergic P2 receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description

PPADS tetrasodium salt is a non-selective purinergic P2 receptor antagonist (IC50 values are 1-4 µM at recombinant P2X1, P2X2, P2X3, and P2X5, P2X7 and 28 µM at P2X4 receptors).


PPADS also blocks P2Y1-like and P2Y1 receptors coupled to PLC (pA2 = 6), some P2Y2-like and P2Y4 receptors (IC50 values are 0.9 and 15 µM respectively).


PPADS shows a variety of biological actions. Active in vivo.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Pyridoxalphosphate-6-azophenyl-2',4'- disulfonic acid tetrasodium salt
Molecular Weight 599.3
Chemical structure PPADS tetrasodium salt [192575-19-2] Chemical Structure
Molecular Formula C14H10N3Na4O12PS2
CAS Number 192575-19-2
PubChem identifier 50937405
SMILES CC1=NC(=NNC2=C(C=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])C(=C(C1=O)C=O)COP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
Source Synthetic
InChi InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;/h2-5,16H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;/q;4*+1/p-4
InChiKey ZNPHTQDEBMCNDG-UHFFFAOYSA-J
MDL number MFCD11046026
Appearance Orange solid

References for PPADS tetrasodium salt

References are publications that support the biological activity of the product

  • Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels.

    Ziganshin et al (1994) Br J Pharmacol. 111(3) : 923-9
    Read more (PubMedID: 8019770)

  • Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens.

    McLaren et al (1994) Br J Pharmacol. 111(3) : 913-7
    Read more (PubMedID: 8019769)

  • PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses.

    Lambrecht et al (1992) Eur J Pharmacol. 217(2-3) : 217-9
    Read more (PubMedID: 1330591)

3 Item(s)

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Grouped product items
Order: HB1950
Pack PriceQty
10mg
$54
50mg
$232
250mg
$865
Non-selective purinergic P2 receptor antagonist
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