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γ-DGG (γ-D-glutamylglycine) product vial image | Hello Bio
γ-DGG (γ-D-glutamylglycine) product vial image | Hello Bio
Biological Data
| Biological description | Broad spectrum glutamate antagonist. Low affinity, rapidly dissociating competitive AMPA receptor antagonist which blocks AMPAR-mediated EPSCs. Also an non-selective NMDA receptor antagonist. Shows anti-depressant actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in NaOH(aq) (100mM, gentle warming) or water (100mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | γ-D-Glutamylglycine |
| Chemical structure | ![γ-DGG (γ-D-glutamylglycine) [6729-55-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "γ-DGG (γ-D-glutamylglycine) [6729-55-1]") |
| Molecular Formula | C7H12N2O5 |
| PubChem identifier | 6604701 |
| SMILES | O=C(CC[C@@H](N)C(=O)O)NCC(=O)O |
| InChiKey | ACIJGUBIMXQCMF-SCSAIBSYSA-N |
References for gamma-DGG / γ-DGG (γ-D-glutamylglycine)
References are publications that support the biological activity of the product
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Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons.
Guzman RE et al (2014) Front Cell Neurosci 8 : 143 -
Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity.
Aksenov DP et al (2005) J Neurophysiol 93(1) : 44-52. -
Depressant actions of gamma-D-glutamylaminomethyl sulfonate (GAMS) on amino acid-induced and synaptic excitation in the cat spinal cord.
Davies J et al (1985) Brain Res 327(1-2) : 113-20.
Broad spectrum glutamate antagonist
![γ-DGG (γ-D-glutamylglycine) [6729-55-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0680.png "γ-DGG (γ-D-glutamylglycine) [6729-55-1]")
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