Product overview
| Name | (-)-MK 801 maleate |
| Description | NMDA receptor antagonist. Less active enantiomer of (+)-MK 801. |
| Alternative names | Dizocilpine maleate, Dizocilpine |
| Purity | >99% |
Write Your Own Review
Biological Data
| Biological description | NMDA receptor antagonist which is the less active enantiomer of (+)-MK 801 maleate. It shows approximately 10-fold reduction in potency compared to (+)-MK 801 maleate. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (25mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (5R,10S)-(-)-5-Methyl-10,11-dihydro -5H-dibenzo[a,d]cylcohepten-5,10-imine maleate |
| Molecular Weight | 337.37 |
| Chemical structure | ![(-)-MK 801 maleate [121917-57-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0003.png "(-)-MK 801 maleate [121917-57-5]") |
| Molecular Formula | C16H15N.C4H4O4 |
| CAS Number | 121917-57-5 |
| PubChem identifier | 16219612 |
| SMILES | O=C(O)/C=CC(=O)O.C[C@]42N[C@@H](Cc1ccccc12)c3ccccc34 |
| Source | Synthetic |
| InChi | InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1 |
| InChiKey | QLTXKCWMEZIHBJ-FWHYOZOBSA-N |
| Appearance | White solid |
References for (-)-MK 801 maleate
References are publications that support the biological activity of the product
-
Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.
Genovese RF et al (1991) Psychopharmacology (Berl) 105(4) : 477-80. -
The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurologic recovery and histopathology following complete cerebral ischemia in primates.
Lanier WL et al (1990) J Cereb Blood Flow Metab 10(2) : 252-61.
Technical guides
Understanding purity and quality - a guide for life scientistsRelated Products
