Product overview

Name (-)-MK 801 maleate
Description NMDA receptor antagonist. Less active enantiomer of (+)-MK 801.
Alternative names Dizocilpine maleate, Dizocilpine
Purity >99%
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Biological Data

Biological description NMDA receptor antagonist which is the less active enantiomer of (+)-MK 801 maleate. It shows approximately 10-fold reduction in potency compared to (+)-MK 801 maleate.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (25mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (5R,10S)-(-)-5-Methyl-10,11-dihydro -5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Molecular Weight 337.37
Chemical structure (-)-MK 801 maleate  [121917-57-5] Chemical Structure
Molecular Formula C16H15N.C4H4O4
CAS Number 121917-57-5
PubChem identifier 16219612
SMILES O=C(O)/C=CC(=O)O.C[C@]42N[C@@H](Cc1ccccc12)c3ccccc34
Source Synthetic
InChi InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1
InChiKey QLTXKCWMEZIHBJ-FWHYOZOBSA-N
Appearance White solid

References for (-)-MK 801 maleate

References are publications that support the biological activity of the product
  • Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.

    Genovese RF et al (1991) Psychopharmacology (Berl) 105(4) : 477-80.
  • The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurologic recovery and histopathology following complete cerebral ischemia in primates.

    Lanier WL et al (1990) J Cereb Blood Flow Metab 10(2) : 252-61.