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Biological Data
| Biological description | Potent and selective α7 nicotinic receptor antagonist (Ki = 1.4 nM). Shows protective effects against amyloid beta cytotoxicity. Active in vivo. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (100 mM) and in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16 -tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrroli dinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate |
| Chemical structure | ![Methyllycaconitine citrate [112825-05-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Methyllycaconitine citrate [112825-05-5]") |
| Molecular Formula | C37H50N2O10.C6H8O7 |
| PubChem identifier | 124081005 |
| SMILES | CCN1C[C@]2(CC[C@H]([C@@]34[C@@H]2[C@@H]([C@@]([C@@H]31)([C@@]5(C[C@@H]([C@H]6C[C@@H]4[C@@H]5[C@H]6OC)OC)O)O)OC)OC)COC(=O)C7=CC=CC=C7N8C(=O)C[C@H](C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
| InChi | InChI=1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-4 |
| InChiKey | INBLZNJHDLEWPS-OXVGBIBJSA-N |
Publications
These publications cite the use of Methyllycaconitine citrate (MLA) purchased from Hello Bio:
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Differential regulation of prelimbic and thalamic transmission to the basolateral amygdala by acetylcholine receptors
Mott et al (2021) bioRxiv https://doi.org/10.1101/2021.12.28.474396 : doi
Potent, selective α7 nicotinic receptor antagonist
![Methyllycaconitine citrate [112825-05-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2026.png "Methyllycaconitine citrate [112825-05-5]")
Understanding purity and quality - a guide for life scientists
