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MDCPG

(HB1602)
Publications (1)
Technical documents: SDS Datasheet
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Product overview

Name MDCPG
Alternative names (RS)-MDCPG
Description Selective mGlu8 receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Reviews Publications (1) References (2) Frequently bought together
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MDCPG product vial image | Hello Bio
MDCPG product vial image | Hello Bio

MDCPG product vial image | Hello Bio

MDCPG product vial image | Hello Bio

Biological Data

Biological description Selective mGlu8 receptor antagonist (Ki = 2.3 μM in mouse hippocampal slices). Can be used to distinguish actions of DCPG on mGlu8 receptors versus off-target effects on mGlu2 receptors. Also shown to reverse DCPG induced long term depression.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in 0.1M NaOH (100mM) and in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (RS)-4-(1-Amino-1-carboxyethyl)phthalic acid
Molecular Weight 253.06
Chemical structure MDCPG Chemical Structure
Molecular Formula C11H11NO6
PubChem identifier 91996985
SMILES CC(C1=CC(=C(C=C1)C(=O)O)C(=O)O)(C(=O)O)N
InChi InChI=1S/C11H11NO6/c1-11(12,10(17)18)5-2-3-6(8(13)14)7(4-5)9(15)16/h2-4H,12H2,1H3,(H,13,14)(H,15,16)(H,17,18)
InChiKey IGLGZJSKFBLMKQ-UHFFFAOYSA-N

References for MDCPG

References are publications that support the biological activity of the product

  • Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

    Mercier MS et al (2013) Neuropharmacology 67 : 294-303
    Read more (PubMedID: 23220400)

  • Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.

    Lodge D et al (2013) Neuropharmacology 74 : 135-46
    Read more (PubMedID: 23542080)

2 Item(s)

Publications
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These publications cite the use of MDCPG purchased from Hello Bio:

  • Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain

    Boccella S et al (2019) Int J Mol Sci 20(7) : E1757
    PubMedID: 30970677

1 Item

Related Products
Grouped product items
Order: HB1602
Pack PriceQty
10mg
$263
50mg
$1,112
Selective mGlu8 receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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