Selective mGlu8 receptor antagonist (Ki = 2.3 μM in mouse hippocampal slices). Can be used to distinguish actions of DCPG on mGlu8 receptors versus off-target effects on mGlu2 receptors. Also shown to reverse DCPG induced long term depression.
Solubility & Handling
Solubility overview
Soluble in 0.1M NaOH (100mM) and in DMSO
Storage instructions
+4°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
These publications cite the use of MDCPG purchased from Hello Bio:
Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain
Boccella S et al (2019) Int J Mol Sci 20(7) : E1757
Understanding purity and quality - a guide for life scientists
