Nω-Propyl-L-arginine hydrochloride

(HB0466)
Technical documents: Datasheet

Product overview

Name Nω-Propyl-L-arginine hydrochloride
Alternative names L-NPA
Purity >98%
Description Potent, selective nNOS inhibitor
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Biological Data

Biological description Potent and selective nNOS inhibitor (Ki = 50 nM). Highly selective for nNOS over eNOS and iNOS. Shows anti-convulsant actions and decreases blood pressure.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100nM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
Molecular Weight 252.74
Chemical structure Nω-Propyl-L-arginine hydrochloride  [137361-05-8] Chemical Structure
Molecular Formula C9H20N4O2.HCl
CAS Number 137361-05-8
PubChem identifier 447180
SMILES N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl
InChiKey AOMXURITGZJPKB-ZETCQYMHSA-N

References for Nω-Propyl-L-arginine hydrochloride

References are publications that support the biological activity of the product
  • N(w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.

    Beamer E et al (2012) Eur J Neurosci 36(9) : 3194-203.
  • The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.

    Kakoki M et al (2001) Am J Physiol Regul Integr Comp Physiol 281(1) : R91-7.
  • The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.

    Kakoki M et al (2001) Am J Physiol Regul Integr Comp Physiol 281(1) : R91-7.
  • Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.

    Zhang HQ et al (1997) J Med Chem 40(24) : 3869-70.

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