Non-selective protein kinase inhibitor (IC50 values are 10-30 nM for serine/threonine protein kinases). PKC and Ca2+ / calmodulin-stimulated phosphodiesterase inhibitor (IC50 values are 32.9 nM and 1.8 - 2.8 µM respectively). Competitively inhibits myosin light chain kinase (MLCK) - may interact with the ATP-binding domain (Ki = 20 nM). Blocks neuronal differentiation by potently inhibiting NGF receptor gp140trk tyrosine protein kinase (IC50 = 3nM). Cell permeable and shows potential anti-tumor actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (1mg/ml) or DMF (1mg/ml)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![K-252a [99533-80-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0351.png "K-252a [99533-80-9]")
Understanding purity and quality - a guide for life scientists
