Product overview

Name Iperoxo

Potent muscarinic acetylcholine receptor superagonist. Also binds the hM3R-miniGq DREADD receptor.

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Biological Data

Biological description

Potent muscarinic acetylcholine receptor (mAChR) superagonist (EC50 = 2.12 and 8.47 at M2 and M4 respectively). Used to solve the WT-hM3R structure. Recently used to report the cryogenic electron microscopy high-resolution structure of the hM3R-miniGq DREADD receptor complex to provide an insight into the agonist selectivity of DREADDs. This may assist structure-guided discovery of further chemogenetic tools.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (50 mM), and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 4-[(4,5-dihydro-1,2-oxazol-3-yl)oxy]-N,N,N-trimethylbut-2-yn-1-aminium iodide
Molecular Weight 324.16
Chemical structure  Chemical Structure
Molecular Formula C10H17IN2O2
Source Synthetic
InChi InChI=1S/C10H17N2O2.HI/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10;/h6-9H2,1-3H3;1H/q+1;/p-1

References for Iperoxo

References are publications that support the biological activity of the product
  • Molecular basis for selective activation of DREADD-based chemogenetics.

    Zhang S et al (2022) Nature 612 : 354-362
  • New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo.

    Schrage R et al (2014) Biochemical pharmacology 90 : 307-19
  • Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.

    Schrage R et al (2013) British journal of pharmacology 169 : 357-70

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