Potent muscarinic acetylcholine receptor (mAChR) superagonist (EC50 = 2.12 and 8.47 at M2 and M4 respectively). Used to solve the WT-hM3R structure. Recently used to report the cryogenic electron microscopy high-resolution structure of the hM3R-miniGq DREADD receptor complex to provide an insight into the agonist selectivity of DREADDs. This may assist structure-guided discovery of further chemogenetic tools.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in water (50 mM), and in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Understanding purity and quality - a guide for life scientists
