Product overview

Name (-)-Huperzine A
Alternative names Hup A.
Purity >97%
Description AChE inhibitor / NMDA receptor antagonist
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Biological Data

Biological description Acetylcholinesterase inhibitor (Ki = 6.2 nM). Also NMDA receptor antagonist (Ki = 6 μM at PCP site). Blood brain barrier permeable. Promotes hippocampal neurogenesis. Displays potent antinociceptive and anticonvulsant properties. Also shows positive effects on improving cognitive and behavioural functions.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO or Ethanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >97%
Chemical name (1R,9S,13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[,7]trideca-2(7),3,10-trien-5-one
Molecular Weight 242.32
Chemical structure (-)-Huperzine A  [102518-79-6] Chemical Structure
Molecular Formula C15H18N2O
CAS Number 102518-79-6
PubChem identifier 907504

References for (-)-Huperzine A

References are publications that support the biological activity of the product
  • Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.

    Ma T et al (2013) Brain Res 1506 : 35-43.
  • Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.

    Park P et al (2010) Neurosci Lett 470(1) : 6-9.
  • The NMDA receptor ion channel: a site for binding of Huperzine A.

    Gordon RK et al (2001) J Appl Toxicol 21 Suppl 1 : S47-51.
  • Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.

    Saxena A et al (1994) Protein Sci 3(10) : 1770-8.

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