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(-)-Huperzine A

(HB0001)
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Product overview

Name (-)-Huperzine A
Alternative names Hup A.
Purity >97%
Description AChE inhibitor / NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Acetylcholinesterase inhibitor (Ki = 6.2 nM). Also NMDA receptor antagonist (Ki = 6 μM at PCP site). Blood brain barrier permeable. Promotes hippocampal neurogenesis. Displays potent antinociceptive and anticonvulsant properties. Also shows positive effects on improving cognitive and behavioural functions.

Solubility & Handling

Solubility overview Soluble in DMSO or Ethanol
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >97%
Chemical name (1R,9S,13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
Molecular Weight 242.32
Chemical structure (-)-Huperzine A [102518-79-6] Chemical Structure
Molecular Formula C15H18N2O
CAS Number 102518-79-6
PubChem identifier 907504
SMILES CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3

References for (-)-Huperzine A

References are publications that support the biological activity of the product

  • Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.

    Ma T et al (2013) Brain Res 1506 : 35-43.
    Read more (PubMedID: 23454433)

  • Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.

    Park P et al (2010) Neurosci Lett 470(1) : 6-9.
    Read more (PubMedID: 20026382)

  • The NMDA receptor ion channel: a site for binding of Huperzine A.

    Gordon RK et al (2001) J Appl Toxicol 21 Suppl 1 : S47-51.
    Read more (PubMedID: 11920920)

  • Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.

    Saxena A et al (1994) Protein Sci 3(10) : 1770-8.
    Read more (PubMedID: 7849595)

4 Item(s)

Related Products
Grouped product items
Order: HB0001
Pack PriceQty
2mg
$147
5mg
$202
10mg
$351
50mg
$1,126
AChE inhibitor / NMDA receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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