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Biological Data Biological description Phytoestrogen. Protein tyrosine inhibitor and PPARγ and PPARα agonist (Ki values = 5.7 nM at PPARγ). Also binds estrogen receptors to exert weak estrogenic activity. Shows variety of biological actions.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4 H -1-benzopyran-4-one
Chemical structure
Molecular Formula C15 H10 O5
PubChem identifier 5280961
SMILES OC1=CC=C(C=C1)C1=COC2=C(C(O)=CC(O)=C2)C1=O
InChi InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
InChiKey TZBJGXHYKVUXJN-UHFFFAOYSA-N
References for Genistein References are publications that support the biological activity of the product
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Wang L et al (2014) Biochem Pharmacol 92(1) : 73-89. Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer. Nakamura H et al (2011) PLoS One 6(5) : e20034. Genistein, a specific inhibitor of tyrosine-specific protein kinases. Akiyama T et al (1987) J Biol Chem 262(12) : 5592-5.
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Protein tyrosine kinase inhibitor and PPARγ agonist. Phytoestrogen.