Product overview

Name Genistein
Description Protein tyrosine kinase inhibitor and PPARγ agonist. Phytoestrogen.
Purity >98%
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Biological Data

Biological description Phytoestrogen. Protein tyrosine inhibitor and PPARγ and PPARα agonist (Ki values = 5.7 nM at PPARγ). Also binds estrogen receptors to exert weak estrogenic activity. Shows variety of biological actions.

Solubility & Handling

Storage instructions -20°C (desiccate)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4 H-1-benzopyran-4-one
Molecular Weight 270.24
Chemical structure Genistein Chemical Structure
Molecular Formula C15H10O5
CAS Number 446-72-0
PubChem identifier 5280961
SMILES OC1=CC=C(C=C1)C1=COC2=C(C(O)=CC(O)=C2)C1=O
InChiKey TZBJGXHYKVUXJN-UHFFFAOYSA-N

References for Genistein

References are publications that support the biological activity of the product
  • Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.

    Wang L et al (2014) Biochem Pharmacol 92(1) : 73-89.
  • Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer.

    Nakamura H et al (2011) PLoS One 6(5) : e20034.
  • Genistein, a specific inhibitor of tyrosine-specific protein kinases.

    Akiyama T et al (1987) J Biol Chem 262(12) : 5592-5.