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Fluorescently labeled Muscimol TMR-X conjugate

(HB6110)
Publications (4)
Technical documents: SDS CoA Datasheet
1  Review
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Product overview

Name Fluorescently labeled Muscimol TMR-X conjugate
Biological description

This fluorescently labelled muscimol conjugate exhibits agonist activity GABAA and GABAC receptors.

The compound is active in vivo and shows no difference to muscimol  on long-term contextual fear. The fluorescently labeled Muscimol TMR-X conjugate can be considered to be representative for the diffusion of muscimol after dorsohippocampal administration.

The compound can be used for visulazing the spatial gradient of reversible brain inactivations.

Alternative names Muscimol-bodipy, Muscimol-BODIPY® TMR-X conjugate (TM of Molecular Probes)
Purity >98%
Description Fluorescently labeled Muscimol
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) Publications (4) References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C (desiccate, protect from light)
Solubility overview Soluble in DMSO and in MeOH
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 5,5-difluoro-2-(3-((6-(((3-hydroxyisoxazol-5-yl)methyl)amino)-6-oxohexyl)amino)-3-oxopropyl)-7-(4-methoxyphenyl)-1,3-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
Molecular Weight 607.46
Molecular Formula C31H36BF2N5O5
Excitation 544
Emission 570

References for Fluorescently labeled Muscimol TMR-X conjugate

References are publications that support the biological activity of the product

  • GABA(A) receptor activation in the CA1 area of the dorsal hippocampus impairs consolidation of conditioned contextual fear in C57BL/6J mice.

    Misane et al (2013) Behav Brain Res. 238 : 160-9
    Read more (PubMedID: 23098796)

  • Imaging the spread of reversible brain inactivations using fluorescent muscimol.

    Allen (2008) J Neurosci Methods 171(1) : 30-8
    Read more (PubMedID: 18377997)

  • Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment.

    Vu et al (2005) Biomaterials 26(14) : 1895-903
    Read more (PubMedID: 15576163)

3 Item(s)

Publications
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These publications cite the use of Fluorescently labeled Muscimol TMR-X conjugate purchased from Hello Bio:

  • Execution of new trajectories toward a stable goal without a functional hippocampus.

    Duszkiewicz AJ et al (2023) Hippocampus 33 : 769-786
    PubMedID: 36798045

  • Cortico-Cortical Pathway Targets Inhibitory Interneurons and Modulates Paw Movement during Locomotion in Mice

    Chang et al (2022) J Neurosci. 42(1) : 44-57
    PubMedID: 34759028

  • Cortico-Cortical Feedback in Mouse S1 Regulates Motor Coordination Via Inhibitory Interneurons

    Chang et al et al (2021) Current Biology 37

  • Silent learning

    Rossato et al (2018) Current Biology 28 : 1-8

4 Item(s)

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1mg
$436
Fluorescently labeled Muscimol
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