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Exendin-4

(HB3157)
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Product overview

Name Exendin-4
Biological description

Overview

Exendin-4 is a potent glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM). It shares 53% amino-acid sequence identity to mammalian GLP-1.

Uses & applications

Exendin-4 shows similar biological actions to GLP-1 and has many glucoregulatory actions. For example, in a glucose dependent manner, it enhances insulin secretion, supresses inappropriately high glucagon section, slows gastric emptying and reduces food intake.

It has also confers cardioprotection after myocardial infarction and provides neuroprotective actions.

It additionally modulates cell-survival mechanisms in various types of cells.

Alternative names Ex-4, Exenatide , AC 2993
Purity >95%
Description

Potent GLP-1 receptor agonist

Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS (Ser-39 = C-terminal amide)
Molecular Weight 4186.63
Chemical structure Exendin A [141758-74-9] Chemical Structure
Molecular Formula C184H282N50O60S
Sequence (one letter) HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Sequence (three letter) His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser
Modifications Ser-39 = C-terminal amide
CAS Number 141758-74-9
PubChem identifier 45588096
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CC9=CNC=N9)N
InChiKey HTQBXNHDCUEHJF-XWLPCZSASA-N
MDL number MFCD00240171
Protein length 39

References for Exendin-4

References are publications that support the biological activity of the product

  • Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia

    Teramoto S et al (2011) J Cereb Blood Flow Metab 31(8) : 1696-705
    Read more (PubMedID: 21487412)

  • Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes

    Nielsen LL et al (2004) Regul Pept 117(2) : 77-88
    Read more (PubMedID: 14700743)

  • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells

    Göke R et al (1993) J Biol Chem 268(26) : 19650-5
    Read more (PubMedID: 8396143)

3 Item(s)

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Order: HB3157
Pack PriceQty
500μg
$196
1mg
$333

Potent GLP-1 receptor agonist

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