My Cart
My account
Menu
Main Menu

Exendin-4

(HB3157)
Be the first to add a publication
Technical documents: SDS CoA Datasheet
1  Review
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name Exendin-4
Biological description

Overview

Exendin-4 is a potent glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM). It shares 53% amino-acid sequence identity to mammalian GLP-1.

Uses & applications

Exendin-4 shows similar biological actions to GLP-1 and has many glucoregulatory actions. For example, in a glucose dependent manner, it enhances insulin secretion, supresses inappropriately high glucagon section, slows gastric emptying and reduces food intake.

It has also confers cardioprotection after myocardial infarction and provides neuroprotective actions.

It additionally modulates cell-survival mechanisms in various types of cells.

Alternative names Ex-4, Exenatide , AC 2993
Purity >95%
Description

Potent GLP-1 receptor agonist

Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (3) Frequently bought together
Write Your Own Review
You're reviewing:Exendin-4
Rate this item:

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
Chemical name HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS (Ser-39 = C-terminal amide)
Molecular Weight 4186.63
Chemical structure Exendin A [141758-74-9] Chemical Structure
Molecular Formula C184H282N50O60S
Sequence (one letter) HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Sequence (three letter) His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser
Modifications Ser-39 = C-terminal amide
CAS Number 141758-74-9
PubChem identifier 45588096
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CC9=CNC=N9)N
InChiKey HTQBXNHDCUEHJF-XWLPCZSASA-N
MDL number MFCD00240171
Protein length 39

References for Exendin-4

References are publications that support the biological activity of the product

  • Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia

    Teramoto S et al (2011) J Cereb Blood Flow Metab 31(8) : 1696-705
    Read more (PubMedID: 21487412)

  • Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes

    Nielsen LL et al (2004) Regul Pept 117(2) : 77-88
    Read more (PubMedID: 14700743)

  • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells

    Göke R et al (1993) J Biol Chem 268(26) : 19650-5
    Read more (PubMedID: 8396143)

3 Item(s)

Related Products
Grouped product items
Order: HB3157
Pack PriceQty
500μg
$204
1mg
$347

Potent GLP-1 receptor agonist

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

Orexin B (human)
Code:
HB5323
Pack:
500μg
Price:
$147
Excitatory neuropeptide at orexin OX1/OX2 receptors
6-Hydroxydopamine (6-OHDA) hydrobromide
Code:
HB1889
Pack:
50mg, 250mg, 1g
Price:
$65, $122, $410
Neurotoxin, widely used to produce the 6-OHDA Parkinson’s disease model
Orexin A (human, rat, mouse)
Code:
HB2937
Pack:
100μg, 500μg, 1mg
Price:
$147, $363, $491
(Free trial)
Excitatory neuropeptide at orexin OX1/OX2 receptors