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Biological Data Biological description Broad-spectrum antibiotic. Tetracycline analog. Also acts as a matrix metalloprotease (MMP) inhibitor.
Commonly used in the inducible Tet-on/ Tet-off gene expression system to control transcription.
Recently used to develop a doxycycline-inducible, viral mediated CRISPR/Cas9 system.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM) and water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate
Chemical structure
Molecular Formula C22 H24 N2 O8 .HCl.0.5H2 O.0.5C2 H6 O
PubChem identifier 54686898
SMILES CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
InChi InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
InChiKey OJMDBNRHBLXJLF-LJTDZVLQSA-N
Appearance Pale yellow to yellow
References for Doxycycline hyclate References are publications that support the biological activity of the product
Inducible in vivo genome editing with CRISPR-Cas9. Dow et al (2015) Nat Biotechnol 33(4) : 390-394 The Development of a Viral Mediated CRISPR/Cas9 System with Doxycycline Dependent gRNA Expression for Inducible In vitro and In vivo Genome Editing. de Solis et al (201 6) Front. Cell. Neurosci. 18 : 9-70 Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Burggraf et al (2007) Neurobiol Dis 25(3) : 506-13
Broad-spectrum antibiotic. Used in inducible Tet-on/ Tet-off gene expression systems for gene editing.
![Doxycycline hyclate [24390-14-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb4608.png "Doxycycline hyclate [24390-14-5]")
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