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RS-1

(HB5647)
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Product overview

Name RS-1
Alternative names RS1, RAD51-Stimulatory Compound-1,
Purity >99%
Description hRAD51 stimulator. Enhances CRISPR genome editing efficiency.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4)
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Biological Data

Biological description

Stimulator of the homologous recombination protein hRAD51. Enhances the DNA binding and homologous recombination activities of hRAD51.


Improves efficiency of HDR (homology-directed repair) 3- to 6-fold (depending on locus and transfection method).

Also enhances Cas9- and TALEN-mediated knock in efficiency in vitro and in vivo. Increases knock-in efficiency in vitro by 2- to 5-fold at different loci and achieves multi-fold improvement in vivo.

Additionally promotes significant anti-tumor responses.

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Molecular Weight 524.2
Chemical structure RS-1 [312756-74-4] Chemical Structure
Molecular Formula C20H16N2O3SBr2
CAS Number 312756-74-4
PubChem identifier 1039737
SMILES C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br
Source Synthetic
InChi InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
InChiKey SWKAVEUTKGKHSR-UHFFFAOYSA-N
MDL number MFCD00348720
Appearance Brown solid

References for RS-1

References are publications that support the biological activity of the product

  • RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.

    Song et al (2016) Nat Commun 28 : 7-10548
    Read more (PubMedID: 26817820)

  • Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.

    Pinder et al (2015) Nucleic Acids Res. 43(19) : 9379-92
    Read more (PubMedID: 26429972)

  • The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.

    Mason et al (2014) Cancer Res 74(13) : 3546-55
    Read more (PubMedID: 24753542)

  • A chemical compound that stimulates the human homologous recombination protein RAD51.

    Jayathilaka et al (2008) Proc Natl Acad Sci U S A. 105(41) : 15848-53
    Read more (PubMedID: 18840682)

4 Item(s)

Related Products
Grouped product items
Order: HB5647
Pack PriceQty
10mg
$65
50mg
$278
hRAD51 stimulator. Enhances CRISPR genome editing efficiency.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

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