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Biological Data Biological description Stimulator of the homologous recombination protein hRAD51. Enhances the DNA binding and homologous recombination activities of hRAD51.
Also enhances Cas9- and TALEN-mediated knock in efficiency in vitro and in vivo . Increases knock-in efficiency in vitro by 2- to 5-fold at different loci and achieves multi-fold improvement in vivo .
Additionally promotes significant anti-tumor responses.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Chemical structure
Molecular Formula C20 H16 N2 O3 SBr2
PubChem identifier 1039737
SMILES C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br
InChi InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
InChiKey SWKAVEUTKGKHSR-UHFFFAOYSA-N
References for RS-1 References are publications that support the biological activity of the product
RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Song et al (2016) Nat Commun 28 : 7-10548 Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Pinder et al (2015) Nucleic Acids Res. 43(19) : 9379-92 The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Mason et al (2014) Cancer Res 74(13) : 3546-55 A chemical compound that stimulates the human homologous recombination protein RAD51. Jayathilaka et al (2008) Proc Natl Acad Sci U S A. 105(41) : 15848-53
hRAD51 stimulator. Enhances CRISPR genome editing efficiency.
![RS-1 [312756-74-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb5647_2.png "RS-1 [312756-74-4]")
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