Product overview

Name Disulfiram
Alternative names Tetraethylthiuram disulfide
Purity >97%
Description Reversibly stimulates SERCA Ca2+-ATPase. V-ATPase inhibitor.
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Biological Data

Biological description

Disulfiram reversibly stimulates SERCA Ca2+-ATPase and inhibits V-ATPase (EC50 = 24.8 μM). It also inhibits aldehyde dehydrogenase and matrix metalloproteinases (MMP-2 and-9).

It also inhibits multidrug resistant P-glycoprotein and concanamycin A-sensitive ATP-hydrolysis.

It displays antifungal, anticancer, anti-alcohol activity and also shows antiviral activity. It inhibits the SARS-CoV-2 Mpro protease (IC50 = 9.35 µM) and inhibits viral replication in Vero cells.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (20mM) and in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >97%
Chemical name Bis(diethylthiocarbamyoyl)disulfide
Molecular Weight 296.54
Chemical structure Disulfiram  [97-77-8] Chemical Structure
Molecular Formula C10H20N2S4
CAS Number 97-77-8
PubChem identifier 3117
InChi InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
MDL number MFCD00009048

References for Disulfiram

References are publications that support the biological activity of the product
  • Structure of M pro from SARS-CoV-2 and discovery of its inhibitors

    Yang et al (2020) Nature (78111) : 289-293
  • Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.

    Johnson RM et al (2010) Anal Biochem 398(2) : 203-11.
  • The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo.

    Fisher SJ et al (2010) J Pharmacol Exp Ther 332(1) : 326-33.
  • Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.

    Cho HJ et al (2007) J Biochem Mol Biol 40(6) : 1069-76.
  • Antifungal potential of disulfiram.

    Khan S et al (2007) Nihon Ishinkin Gakkai Zasshi 48(3) : 109-13.

5 Item(s)