Product overview
| Name | Disulfiram |
| Description | Reversibly stimulates SERCA Ca2+-ATPase. V-ATPase inhibitor. |
| Alternative names | Tetraethylthiuram disulfide |
| Purity | >97% |
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Biological Data
| Biological description | Disulfiram reversibly stimulates SERCA Ca2+-ATPase and inhibits V-ATPase (EC50 = 24.8 μM). It also inhibits aldehyde dehydrogenase and matrix metalloproteinases (MMP-2 and-9). It also inhibits multidrug resistant P-glycoprotein and concanamycin A-sensitive ATP-hydrolysis. It displays antifungal, anticancer, anti-alcohol activity and also shows antiviral activity. It inhibits the SARS-CoV-2 Mpro protease (IC50 = 9.35 µM) and inhibits viral replication in Vero cells. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (20mM) and in ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >97% |
| Chemical name | Bis(diethylthiocarbamyoyl)disulfide |
| Molecular Weight | 296.54 |
| Chemical structure | ![Disulfiram [97-77-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1119.png "Disulfiram [97-77-8]") |
| Molecular Formula | C10H20N2S4 |
| CAS Number | 97-77-8 |
| PubChem identifier | 3117 |
| SMILES | CCN(CC)C(=S)SSC(=S)N(CC)CC |
| InChi | InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3 |
| InChiKey | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| MDL number | MFCD00009048 |
References for Disulfiram
References are publications that support the biological activity of the product
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Structure of M pro from SARS-CoV-2 and discovery of its inhibitors
Yang et al (2020) Nature (78111) : 289-293 -
Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.
Johnson RM et al (2010) Anal Biochem 398(2) : 203-11. -
The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo.
Fisher SJ et al (2010) J Pharmacol Exp Ther 332(1) : 326-33. -
Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.
Cho HJ et al (2007) J Biochem Mol Biol 40(6) : 1069-76. -
Antifungal potential of disulfiram.
Khan S et al (2007) Nihon Ishinkin Gakkai Zasshi 48(3) : 109-13.
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