Figure 1. Citalopram increases positive feedback sensitivity in rats within a probabilistic reward learning task.
Citalopram is a SSRI, widely used to investigate 5-HT neurotransmission. Citalopram from Hello Bio increases positive feedback sensitivity in rats completing a probabilistic reward learning task (Rm-ANOVA, F3,47 = 3.8, p = 0.019).  For protocol see #Protocol 1 in Application Notes below.
Figure 1. Citalopram increases positive feedback sensitivity in rats within a probabilistic reward learning task.
Citalopram is a SSRI, widely used to investigate 5-HT neurotransmission. Citalopram from Hello Bio increases positive feedback sensitivity in rats completing a probabilistic reward learning task (Rm-ANOVA, F3,47 = 3.8, p = 0.019).  For protocol see #Protocol 1 in Application Notes below.
Biological Data
Biological description
Potent, selective 5-HT uptake inhibitor (Ki = 0.75 nM at SERT and IC50 values are 1.8, ~8,000 and ~40,000 nM for 5-HT, noradrenaline and dopamine uptake respectively). Shows antidepressant effects. Active in vivo.
Application notes
Fig 1: Citalopram increases positive feedback sensitivity in rats within a probabilistic reward learning task.
Citalopram is a SSRI, widely used to investigate 5-HT neurotransmission. Citalopram from Hello Bio increases positive feedback sensitivity in rats completing a probabilistic reward learning task (see Fig 1 above, Rm-ANOVA, F3,47 = 3.8, p = 0.019).
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#Protocol 1: Measurement of citalopram induced changes in positive feedback sensitivity within a probabilistic reward learning task.
Lister hooded rats were trained in the probabilistic reversal learning task (see Wilkinson et al, 2020)
Animals were injected with either 0, 1, 3 or 10 mg/kg citalopram in 0.9% saline intraperitoneally 30 minutes before a session.
All animals had all doses of citalopram in a blinded, fully counterbalanced and within subject design.
Positive feedback sensitivity was taken as win-stay probability: the probability that if an animal was rewarded at a stimulus they would return on the next trial.
Statistics: Rm-ANOVA, Main effect of treatment: F3,47 = 3.8, p = 0.019. Sidak corrected posthocs: 3mg/kg vs 0 mg/kg: t33 = 3.0, p = 0.013; 10mg/kg vs 0mg/kg: t33 = 2.6, p = 0.041
Solubility & Handling
Solubility overview
Soluble in water (10mM) and ethanol (50mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Understanding purity and quality - a guide for life scientists
